Materials for stem cell factories of the future

Adam D. Celiz; James G.W. Smith; Robert Langer; Daniel G. Anderson; David A. Winkler; David A. Barrett; Martyn C. Davies; Lorraine E. Young; Chris Denning; Morgan R. Alexander

doi:10.1038/nmat3972

Materials for stem cell factories of the future

Adam D. Celiz, James G.W. Smith, Robert Langer, Daniel G. Anderson, David A. Winkler, David A. Barrett, Martyn C. Davies, Lorraine E. Young, Chris Denning, Morgan R. Alexander

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

24 Downloads (Pure)

Abstract

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4.

Original language	English
Pages (from-to)	570-579
Number of pages	10
Journal	Nature Materials
Volume	13
DOIs	https://doi.org/10.1038/nmat3972
Publication status	Published - 21 May 2014

Keywords

biomaterials
cells
human pluripotent stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nmat3972

Accepted_ManuscriptAccepted author manuscript, 987 KBLicence: Other

http://eprints.nottingham.ac.uk/30875/

Cite this

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title = "Materials for stem cell factories of the future",

abstract = "The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4.",

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AU - Celiz, Adam D.

AU - Smith, James G.W.

AU - Langer, Robert

AU - Anderson, Daniel G.

AU - Winkler, David A.

AU - Barrett, David A.

AU - Davies, Martyn C.

AU - Young, Lorraine E.

AU - Denning, Chris

AU - Alexander, Morgan R.

PY - 2014/5/21

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AB - The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4.

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KW - cells

KW - human pluripotent stem cells

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