Materials for stem cell factories of the future

Adam D. Celiz, James G.W. Smith, Robert Langer, Daniel G. Anderson, David A. Winkler, David A. Barrett, Martyn C. Davies, Lorraine E. Young, Chris Denning, Morgan R. Alexander

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Abstract

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking and to provide the raw material for reproducible differentiation into lineages for large scale drug screening programs and clinical use, wherein >1 billion cells for each patient are needed to replace losses during heart attack, multiple sclerosis and diabetes. Producing this number of cells for one patient is challenging and a rethink is needed to scalable technology with the potential to meet the needs of millions of patients a year. Here we consider the role of materials discovery, an emerging area of materials chemistry that is in a large part driven by the challenges posed by biologists to materials scientists1-4.
Original languageEnglish
Pages (from-to)570-579
Number of pages10
JournalNature Materials
Volume13
DOIs
Publication statusPublished - 21 May 2014

Keywords

  • biomaterials
  • cells
  • human pluripotent stem cells

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