Matrix metalloproteinase genes in Xenopus development

Michael Harrison; Muhammad Abu-Elmagd; Timothy Grocott; Clara Yates; Jelena Gavrilovic; Grant N. Wheeler

doi:10.1002/dvdy.v231:1

Matrix metalloproteinase genes in Xenopus development

Michael Harrison, Muhammad Abu-Elmagd, Timothy Grocott, Clara Yates, Jelena Gavrilovic, Grant N. Wheeler

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52 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are a large family of proteins in vertebrates, consisting of over 24 genes in humans, only a few of which have been identified in Xenopus. Three genes coding for MMPs in Xenopus have been identified and their expression studied during development. The membrane-bound XMMP-14 and -15 (XMT1-MMP and XMT2-MMP) both showed restricted expression patterns, the former principally localising to cranial neural crest tissues and the latter to the epidermis of the embryo. XMMP-7 codes for an MMP that lacks the hemopexin-like domain. It is expressed exclusively in macrophages or other myeloid cell types from early in development.

Original language	English
Pages (from-to)	214-220
Number of pages	7
Journal	Developmental Dynamics
Volume	231
Issue number	1
DOIs	https://doi.org/10.1002/dvdy.v231:1
Publication status	Published - 1 Sep 2004

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AU - Wheeler, Grant N.

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