Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method

Francis H Y Fung, Jonathan C Y Tang, John P P Hopkins, John Dutton, Lisa M Bailey, Andrew S Davison

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Abstract

Teicoplanin is an antibiotic used for the treatment of endocarditis, osteomyelitis, septic arthritis and methicillin-resistant Staphylococcus aureus. Teicoplanin is emerging as a suitable alternative antibiotic to vancomycin, where their trough serum levels are monitored by immunoassay routinely. This is the first report detailing the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring teicoplanin in patients' serum.
Original languageEnglish
Pages (from-to)475-81
Number of pages7
JournalAnnals of Clinical Biochemistry
Volume49
Issue numberPt 5
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Anti-Bacterial Agents
  • Blood Chemical Analysis
  • Chromatography, High Pressure Liquid
  • Humans
  • Limit of Detection
  • Tandem Mass Spectrometry
  • Teicoplanin

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