Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method

Francis H Y Fung; Jonathan C Y Tang; John P P Hopkins; John Dutton; Lisa M Bailey; Andrew S Davison

doi:10.1258/acb.2012.011257

Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method

Francis H Y Fung, Jonathan C Y Tang, John P P Hopkins, John Dutton, Lisa M Bailey, Andrew S Davison

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Abstract

Teicoplanin is an antibiotic used for the treatment of endocarditis, osteomyelitis, septic arthritis and methicillin-resistant Staphylococcus aureus. Teicoplanin is emerging as a suitable alternative antibiotic to vancomycin, where their trough serum levels are monitored by immunoassay routinely. This is the first report detailing the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring teicoplanin in patients' serum.

Original language	English
Pages (from-to)	475-81
Number of pages	7
Journal	Annals of Clinical Biochemistry
Volume	49
Issue number	Pt 5
DOIs	https://doi.org/10.1258/acb.2012.011257
Publication status	Published - Sept 2012

Keywords

Anti-Bacterial Agents
Blood Chemical Analysis
Chromatography, High Pressure Liquid
Humans
Limit of Detection
Tandem Mass Spectrometry
Teicoplanin

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10.1258/acb.2012.011257

Fung et al 2012 TeicoplaninFinal published version, 505 KB

Cite this

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title = "Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method",

abstract = "Teicoplanin is an antibiotic used for the treatment of endocarditis, osteomyelitis, septic arthritis and methicillin-resistant Staphylococcus aureus. Teicoplanin is emerging as a suitable alternative antibiotic to vancomycin, where their trough serum levels are monitored by immunoassay routinely. This is the first report detailing the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring teicoplanin in patients' serum.",

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note = "Fung FH, Tang JC, Hopkins JP, Dutton JJ, Bailey LM, Davison AS. Measurement of teicoplanin by liquid chromatography-tandem mass spectrometry: development of a novel method. Ann Clin Biochem. Sep 2012;49(Pt 5):475-481.",

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KW - Anti-Bacterial Agents

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KW - Chromatography, High Pressure Liquid

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