Measurement properties of adult quality-of-life measurement instruments for eczema: a systematic review

D. Heinl, C. A. C. Prinsen, S. Deckert, J. R. Chalmers, A. M. Drucker, R. Ofenloch, R. Humphreys, T. Sach, S. L. Chamlin, J. Schmitt, C. Apfelbacher

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Background: The Harmonising Outcomes Measures for Eczema (HOME) initiative has identified QoL as a core outcome domain to be evaluated in every eczema trial. It is unclear which of the existing QoL instruments is most appropriate for this domain.
Objective: To systematically assess the measurement properties of existing measurement instruments developed and/or validated for the measurement of QoL in adult eczema.
Methods: We conducted a systematic literature search in PubMed and Embase identifying studies on measurement properties of adult eczema QoL instruments. For all eligible studies, we assessed the adequacy of the measurement properties and the methodological quality with the COnsensus-based Standards for the selection of health status Measurement INstruments (COSMIN) checklist. A best evidence synthesis summarizing findings from different studies was the basis to assign four degrees of recommendation (A-D).
Results: 15 articles reporting on 17 instruments were included. No instrument fulfilled the criteria for category A. Six instruments were placed in category B, meaning that they have the potential to be recommended depending on the results of further validation studies. Three instruments had poor adequacy in at least one required adequacy criterion and were therefore put in category C. The remaining eight instruments were almost not validated at all and were thus placed in category D.
Conclusion: No QoL instrument can be recommended for use in adult eczema. The Quality of Life Index for Atopic Dermatitis (QoLIAD) in five language versions and the Spanish version of the Dermatology Life Quality Index (DLQI) are recommended for further validation research.
Original languageEnglish
Pages (from-to)358-370
Number of pages13
Issue number3
Early online date16 Dec 2015
Publication statusPublished - Mar 2016


  • core outcome set
  • eczema
  • Harmonising Outcome Measures for Eczema initiative
  • measurement properties
  • quality of life

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