Melilotoside derivatives from Artemisia splendens (Asteraceae)

Fariba H. Afshar, Abbas Delazar, Hossein Nazemiyeh, Lutfun Nahar, Sedigheh B. Moghaddam, Blessing O. Mbaebie, Simon Gibbons, Satyajit D. Sarker

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9 Citations (Scopus)


A combination of solid-phase-extraction (SPE) and reversed-phase preparative high-performance liquid chromatography (prep-HPLC) of the methanolic extract of the aerial parts of Artemisia splendens (common name: “Asia Minor Wormwood”), an endemic Iranian species, afforded Z- and E-melilotosides (1 and 2), Z- and E-4-methoxy-melilotosides (3 and 4), and a new dimer, bis-ortho-Z-melilotoside (5, named: splendenoside). Whilst the structures of these compounds (1-5) were elucidated unequivocally by spectroscopic means, the in vitro free-radical-scavenging property of 1-5 was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This is the first report on the occurrence of any melilotoside derivatives in the genus Artemisia.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalRecords of Natural Products
Issue number1
Publication statusPublished - 2017


  • 2,2-diphenyl-1-picrylhydrazyl (DPPH)
  • Artemisia splendens
  • Asteraceae
  • Free-radical scavenger
  • Melilotoside
  • Splendenoside

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