Membrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruzi

Claire Butler, Kevin Tyler

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It is widely accepted that Trypanosoma cruzi can exploit the natural exocytic response of the host to cell damage, utilizing host cell lysosomes as important effectors. It is, though, increasingly clear that the parasite also exploits endocytic mechanisms which allow for incorporation of plasma membrane into the parasitophorous vacuole. Further, that these endocytic mechanisms are involved in cross-talk with the exocytic machinery, in the recycling of vesicles and in the manipulation of the cytoskeleton. Here we review the mechanisms by which T.?cruzi exploits features of the exocytic and endocytic pathways in epithelial and endothelial cells and the evidence for cross-talk between these pathways.
Original languageEnglish
Pages (from-to)1345-1353
Number of pages8
JournalCellular Microbiology
Volume14
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • Trypanosoma cruzi
  • Endocytosis
  • Animals
  • Humans
  • Vacuoles
  • Exocytosis
  • Models, Biological
  • Host-Pathogen Interactions

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