Abstract
Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.
| Original language | English |
|---|---|
| Pages (from-to) | 33-36 |
| Number of pages | 4 |
| Journal | Journal of Alzheimers Disease |
| Volume | 40 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
Keywords
- lv-PPA
- Memory
- na-PPA
- orientation
- PiB
- PPA
Profiles
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Michael Hornberger
- Norwich Medical School - Professor of Applied Dementia Research
- Norwich Institute for Healthy Aging - Member
- Lifespan Health - Member
- Mental Health - Member
Person: Research Group Member, Research Centre Member, Academic, Teaching & Research