Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia

Emma C. Flanagan, Sicong Tu, Samrah Ahmed, John R. Hodges, Michael Hornberger

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15 Citations (Scopus)

Abstract

Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.

Original languageEnglish
Pages (from-to)33-36
Number of pages4
JournalJournal of Alzheimer's Disease
Volume40
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • lv-PPA
  • Memory
  • na-PPA
  • orientation
  • PiB
  • PPA

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