Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia

Emma C. Flanagan; Sicong Tu; Samrah Ahmed; John R. Hodges; Michael Hornberger

doi:10.3233/JAD-131448

Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia

Emma C. Flanagan, Sicong Tu, Samrah Ahmed, John R. Hodges, Michael Hornberger

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20 Citations (Scopus)

Abstract

Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Journal of Alzheimers Disease
Volume	40
Issue number	1
DOIs	https://doi.org/10.3233/JAD-131448
Publication status	Published - 2014

Keywords

lv-PPA
Memory
na-PPA
orientation
PiB
PPA

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abstract = "Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.",

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AU - Ahmed, Samrah

AU - Hodges, John R.

AU - Hornberger, Michael

PY - 2014

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AB - Memory and orientation were investigated as predictors of underlying Alzheimer's disease (AD) pathology in patients with logopenic (lv) and non-fluent (na) variants of primary progressive aphasia (PPA). Memory and orientation scores from Addenbrooke's Cognitive Examination were compared between 26 lv-PPA, 29 na-PPA, 59 AD, and 90 controls using analysis of variance. Forty-five patients underwent Pittsburgh compound B (PiB) positron emission tomography scans. Patients with lv-PPA performed poorer on memory and orientation than na-PPA and did not differ from the AD group. Post-hoc analysis on the PiB-scanned subgroup corroborated these results. Memory and orientation profiles may supplement language assessment in identifying patients with AD pathology.

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Memory and orientation in the logopenic and nonfluent subtypes of primary progressive aphasia

Abstract

Keywords

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