TY - JOUR
T1 - Memory control deficits in the sleep-deprived human brain
AU - Harrington, Marcus O.
AU - Karapanagiotidis, Theodoros
AU - Phillips, Lauryn
AU - Smallwood, Jonathan
AU - Anderson, Michael C.
AU - Cairney, Scott A.
N1 - Data, Materials, and Software Availability: Study data is publicly available via the following link: https://osf.io/jfdbx/?view_only=175ffc1f9e9249e09d27612cfcaf62ec (75).
Funding information: This work was supported by Medical Research Council Career Development Award No. MR/P020208/1 to S.A.C.
PY - 2025/1/7
Y1 - 2025/1/7
N2 - Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought. We conclude that sleep deprivation gives rise to intrusive memories via the disruption of neural circuits governing mnemonic inhibitory control, which may rely on REM sleep.
AB - Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought. We conclude that sleep deprivation gives rise to intrusive memories via the disruption of neural circuits governing mnemonic inhibitory control, which may rely on REM sleep.
KW - Memory Suppression
KW - Sleep Deprivation
KW - Default Mode Network
KW - Heart Rate Variability
KW - Inhibitory Control
KW - Functional Neuroimaging
KW - sleep deprivation
KW - heart rate variability
KW - inhibitory control
KW - memory suppression |
KW - default mode network
UR - http://www.scopus.com/inward/record.url?scp=85214321521&partnerID=8YFLogxK
U2 - 10.1073/pnas.2400743122
DO - 10.1073/pnas.2400743122
M3 - Article
VL - 122
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 1
M1 - e2400743122
ER -