Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort

G Lace; P G Ince; C Brayne; G M Savva; F E Matthews; R de Silva; J E Simpson; S B Wharton

doi:10.1159/000341581

Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort

G Lace, P G Ince, C Brayne, G M Savva, F E Matthews, R de Silva, J E Simpson, S B Wharton

Norwich Epidemiology Centre

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort.

Original language	English
Pages (from-to)	15-24
Number of pages	10
Journal	Dementia and Geriatric Cognitive Disorders
Volume	34
Issue number	1
DOIs	https://doi.org/10.1159/000341581
Publication status	Published - 2012

Keywords

Aged
Aged, 80 and over
Aging
Apolipoproteins E
Astrocytes
Brain
Brain Chemistry
Cadaver
Cell Shape
Cohort Studies
Disease Progression
Female
Genotype
Hippocampus
Humans
Immunohistochemistry
Male
Neuroglia
Oligodendroglia
Silver Staining
tau Proteins

Access to Document

10.1159/000341581

Cite this

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title = "Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort",

abstract = "Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort.",

keywords = "Aged, Aged, 80 and over, Aging, Apolipoproteins E, Astrocytes, Brain, Brain Chemistry, Cadaver, Cell Shape, Cohort Studies, Disease Progression, Female, Genotype, Hippocampus, Humans, Immunohistochemistry, Male, Neuroglia, Oligodendroglia, Silver Staining, tau Proteins",

author = "G Lace and Ince, {P G} and C Brayne and Savva, {G M} and Matthews, {F E} and {de Silva}, R and Simpson, {J E} and Wharton, {S B}",

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T1 - Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort

AU - Lace, G

AU - Ince, P G

AU - Brayne, C

AU - Savva, G M

AU - Matthews, F E

AU - de Silva, R

AU - Simpson, J E

AU - Wharton, S B

PY - 2012

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N2 - Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort.

AB - Glial tau pathology is seen in certain tauopathies and in ageing. We determined its frequency in ageing mesial temporal lobe and its relationship to other tau pathologies in the MRC-CFAS population-representative neuropathology cohort.

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KW - Aged, 80 and over

KW - Aging

KW - Apolipoproteins E

KW - Astrocytes

KW - Brain

KW - Brain Chemistry

KW - Cadaver

KW - Cell Shape

KW - Cohort Studies

KW - Disease Progression

KW - Female

KW - Genotype

KW - Hippocampus

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Neuroglia

KW - Oligodendroglia

KW - Silver Staining

KW - tau Proteins

U2 - 10.1159/000341581

DO - 10.1159/000341581

M3 - Article

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SN - 1421-9824

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JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

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