Meta-analysis of Tpeak –Tend and Tpeak –Tend /QT ratio for risk stratification in congenital long QT syndrome

Gary Tse, Mengqi Gong, Lei Meng, Cheuk Wai Wong, Stamatis Georgopoulos , George Bazoukis, Martin C. S. Wong, Konstantinos P. Letsas, Vassilios S. Vassiliou, Yunlong Xia, Adrian M. Baranchuk, Gan-Xin Yan, Tong Liu

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Background and objectives: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak–Tend interval and the Tpeak–Tend/QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak–Tend intervals and Tpeak–Tend/QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS.

Method: PubMed and Embase databases were searched until 9th May 2017, identifying 199 studies.

Results: Five studies on long QT syndrome were included in the final meta-analysis. Tpeak–Tend intervals were longer (mean difference [MD]: 13 ms, standard error [SE]: 4 ms, P = 0.002; I2 = 34%) in congenital LQTS patients with adverse events [syncope, ventricular arrhythmias or sudden cardiac death] compared to LQTS patients without such events. By contrast, Tpeak–Tend/QT ratios were not significantly different between the two groups (MD: 0.02, SE: 0.02, P = 0.26; I2 = 0%).

Conclusion: This meta-analysis showed that Tpeak–Tend interval is significant higher in individuals who are at elevated risk of adverse events in congenital LQTS, offering incremental value for risk stratification.
Original languageEnglish
Pages (from-to)396-401
Number of pages6
JournalJournal of Electrocardiology
Issue number3
Early online date6 Mar 2018
Publication statusPublished - May 2018

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