Metabolic reprogramming of periwinkle plant culture

Weerawat Runguphan, Sarah E. O'Connor

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)


We transformed an alkaloid biosynthetic gene with reengineered substrate specificity into Catharanthus roseus. The resulting transgenic plant cell culture produced a variety of unnatural alkaloid compounds when cocultured with simple, achiral, commercially available precursors that the reengineered enzyme was designed to accept. This work demonstrates the power of genetic engineering to retailor the structures of complex alkaloid natural products in plant culture.
Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalNature Chemical Biology
Issue number3
Publication statusPublished - 2009

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