Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

Jamie V. de Seymour; Stephanie Tu; Xiaoling He; Hua Zhang; Ting Li Han; Philip N. Baker; Karolina Sulek

doi:10.1007/s11306-018-1371-7

Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

Jamie V. de Seymour, Stephanie Tu, Xiaoling He, Hua Zhang, Ting Li Han, Philip N. Baker, Karolina Sulek

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP.

Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry.

Results: Of 105 metabolites detected in hair, none were significantly associated with ICP.

Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

Original language	English
Article number	79
Pages (from-to)	1-5
Number of pages	5
Journal	Metabolomics
Volume	14
Issue number	6
DOIs	https://doi.org/10.1007/s11306-018-1371-7
Publication status	Published - 26 May 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Gas chromatography–mass spectrometry
Hair
Intrahepatic cholestasis of pregnancy
Metabolomics

Access to Document

10.1007/s11306-018-1371-7

Cite this

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title = "Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy",

abstract = "Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP. Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry. Results: Of 105 metabolites detected in hair, none were significantly associated with ICP. Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.",

keywords = "Gas chromatography–mass spectrometry, Hair, Intrahepatic cholestasis of pregnancy, Metabolomics",

author = "{de Seymour}, {Jamie V.} and Stephanie Tu and Xiaoling He and Hua Zhang and Han, {Ting Li} and Baker, {Philip N.} and Karolina Sulek",

note = "The authors would like to acknowledge Associate Professor Silas Villas Boas for his contributions to the hair metabo-lomics method development",

year = "2018",

month = may,

day = "26",

doi = "10.1007/s11306-018-1371-7",

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T1 - Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

AU - de Seymour, Jamie V.

AU - Tu, Stephanie

AU - He, Xiaoling

AU - Zhang, Hua

AU - Han, Ting Li

AU - Baker, Philip N.

AU - Sulek, Karolina

N1 - The authors would like to acknowledge Associate Professor Silas Villas Boas for his contributions to the hair metabo-lomics method development

PY - 2018/5/26

Y1 - 2018/5/26

N2 - Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP. Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry. Results: Of 105 metabolites detected in hair, none were significantly associated with ICP. Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

AB - Introduction: Intrahepatic cholestasis of pregnancy (ICP) is a common maternal liver disease; development can result in devastating consequences, including sudden fetal death and stillbirth. Currently, recognition of ICP only occurs following onset of clinical symptoms. Objective: Investigate the maternal hair metabolome for predictive biomarkers of ICP. Methods: The maternal hair metabolome (gestational age of sampling between 17 and 41 weeks) of 38 Chinese women with ICP and 46 pregnant controls was analysed using gas chromatography–mass spectrometry. Results: Of 105 metabolites detected in hair, none were significantly associated with ICP. Conclusion: Hair samples represent accumulative environmental exposure over time. Samples collected at the onset of ICP did not reveal any metabolic shifts, suggesting rapid development of the disease.

KW - Gas chromatography–mass spectrometry

KW - Hair

KW - Intrahepatic cholestasis of pregnancy

KW - Metabolomics

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Metabolomic profiling of maternal hair suggests rapid development of intrahepatic cholestasis of pregnancy

Abstract

UN SDGs

Keywords

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