Metalloproteinases: their role in arthritis and potential as therapeutic targets

Ian M. Clark, Andrew E. Parker

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)


Irreversible degradation of articular cartilage is a major feature of the arthritides, and its prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix metalloproteinase and ADAMTS (a disintegrin, a metalloproteinase, and thrombospondin motif) families are key mediators of cartilage extracellular matrix destruction. Inhibition of metalloproteinase activity is therefore a conceptually attractive therapeutic strategy, although clinical efficacy has not yet been demonstrated. This review outlines the biology behind metalloproteinases as drug targets in the arthritides, and poses important questions for the future design of such therapies.
Original languageEnglish
Pages (from-to)19-34
Number of pages16
JournalExpert Opinion in Therapeutic Targets
Issue number1
Publication statusPublished - 2003

Cite this