The present invention relates to methods of synthesizing aziridines including isotopically labeled aziridines, said methods comprising contacting an imine or one or more precursors thereof with a diazo compd. in the presence of a phosphoramide or a phosphoramide-derived catalyst. The present invention also relates to aziridines, modified aziridines and aziridine-derived compds. preparable by the aforementioned methods, and to phosphoramide or phosphoramide-derived catalysts suitable for use in such methods.
|Type||U.S. Pat. Appl.|
|Volume||US 20150166478 A1 20150618|
|Publication status||Published - 2015|