Abstract
The present invention relates to methods of synthesizing aziridines including isotopically labeled aziridines, said methods comprising contacting an imine or one or more precursors thereof with a diazo compd. in the presence of a phosphoramide or a phosphoramide-derived catalyst. The present invention also relates to aziridines, modified aziridines and aziridine-derived compds. preparable by the aforementioned methods, and to phosphoramide or phosphoramide-derived catalysts suitable for use in such methods.
| Original language | English |
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| Type | U.S. Pat. Appl. |
| Volume | US 20150166478 A1 20150618 |
| Publication status | Published - 2015 |