Microalbuminuria in inflammatory bowel disease

N Mahmud, J Stinson, M A O'Connell, T J Mantle, P W Keeling, J Feely, D G Weir, D Kelleher

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Abstract

Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel disease and correlated it with the disease activity in 95 patients with inflammatory bowel disease (ulcerative colitis (n = 52), Crohn's disease (n = 43)) determined by the simple index of Harvey and Bradshaw. Fifty patients were in complete clinical remission and 45 patients had active disease. Microalbuminuria was detected in all patients with inflammatory bowel disease (147 (17) v 18 (2) microgram/min, inflammatory bowel disease v controls mean (SEM), p
Original languageEnglish
Pages (from-to)1599-1604
Number of pages6
JournalGut
Volume35
Issue number11
DOIs
Publication statusPublished - Nov 1994

Keywords

  • Acute-Phase Reaction
  • Adolescent
  • Adult
  • Aged
  • Albuminuria
  • C-Reactive Protein
  • Chronic Disease
  • Colitis, Ulcerative
  • Crohn Disease
  • Humans
  • Inflammatory Bowel Diseases
  • Middle Aged
  • Prospective Studies
  • Serum Amyloid A Protein

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