Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life

Henrik M. Roager, Catherine Stanton, Lindsay J. Hall

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut microbial metabolism and the resulting small molecules (metabolites) has been rather limited. However, technological and computational advances are now enabling researchers to profile the plethora of metabolites in the infant gut, allowing for improved understanding of how gut microbial-derived metabolites drive microbiome community structuring and host-microbial interactions. Here, we review the current knowledge on development of the infant gut microbiota and metabolism within the first year of life, and discuss how these microbial metabolites are key for enhancing our basic understanding of interactions during the early life developmental window.
Original languageEnglish
Article number2192151
JournalGut Microbes
Issue number1
Early online date21 Mar 2023
Publication statusPublished - 2023


  • Metabolites
  • diet
  • health
  • host
  • infants
  • metabolomics
  • microbiota

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