Microbiome diversity is a modifiable virulence factor for Cryptosporidiosis

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Abstract

Cryptosporidium spp. infection causes significant disease in immunosuppressed individuals and children under the age of 5 years. The severity of the pathological presentation of cryptosporidiosis is a function of the host and parasite genotypes, host immune status, and the enteric environment or microbiome of the host. Cryptosporidiosis often presents with abdominal pain and severe diarrhoea and is associated with intestinal dysbiosis and inflammation. Our systematic analysis of the available literature revealed that bacterial diversity is reduced during infection in larger animal models, lending support to recent studies which indicate that the use of probiotics or the presence of a naturally diverse gut microbiome can prevent or minimise pathology caused by gastrointestinal pathogens. In summary, we present evidence that the presence of a diverse gut microbiome, natural or induced, reduces both symptomatic pathology and oocyst output.

Original languageEnglish
Article number2273004
JournalVirulence
Volume14
Issue number1
Early online date23 Oct 2023
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Cryptosporidium parvum
  • ;Cryptosporidium hominis
  • gut
  • microbiome
  • microbiota
  • meta-analysis
  • systematic review
  • dysbiosis
  • metagenome

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