Microsatellite instability in human testicular germ cell tumours

R. A. Huddart; R. Wooster; A. Horwich; C. S. Cooper

doi:10.1038/bjc.1995.387

Microsatellite instability in human testicular germ cell tumours

R. A. Huddart
, R. Wooster
, A. Horwich
, C. S. Cooper

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.

Original language	English
Pages (from-to)	642-645
Number of pages	4
Journal	British Journal of Cancer
Volume	72
Issue number	3
DOIs	https://doi.org/10.1038/bjc.1995.387
Publication status	Published - 1 Sept 1995

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Microsatellite instability
Testicular germ cell tumours

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10.1038/bjc.1995.387

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title = "Microsatellite instability in human testicular germ cell tumours",

abstract = "DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21\%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.",

keywords = "Microsatellite instability, Testicular germ cell tumours",

author = "Huddart, \{R. A.\} and R. Wooster and A. Horwich and Cooper, \{C. S.\}",

note = "Funding Information: Acknowled We thank Christine Bell for typing this manuscript and Dr M Stratton. Dr P Karran and Professor R Lahue for helpful discussion. This work is funded by grants from the Cancer Research Campaign. RH is supported by a CRC Clinical Research Fellowship.",

year = "1995",

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doi = "10.1038/bjc.1995.387",

language = "English",

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T1 - Microsatellite instability in human testicular germ cell tumours

AU - Huddart, R. A.

AU - Wooster, R.

AU - Horwich, A.

AU - Cooper, C. S.

N1 - Funding Information: Acknowled We thank Christine Bell for typing this manuscript and Dr M Stratton. Dr P Karran and Professor R Lahue for helpful discussion. This work is funded by grants from the Cancer Research Campaign. RH is supported by a CRC Clinical Research Fellowship.

PY - 1995/9/1

Y1 - 1995/9/1

N2 - DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.

AB - DNA samples obtained from 29 testicular germ cell tumours have been screened for instability at nine different microsatellite sequences consisting of dinucleotide, trinucleotide and tetranucleotide loci. Overall, in tumours from six (21%) patients we found abnormalities in at least one of the loci examined. Mutation was most frequently found in tetranucleotide and trinucleotide repeats with only a low proportion of alterations in dinucleotide repeats. This pattern of instability is distinct from that reported in colorectal cancer and other cancers that have a high level of alterations in dinucleotide repeats.

KW - Microsatellite instability

KW - Testicular germ cell tumours

UR - https://www.scopus.com/pages/publications/0029134548

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DO - 10.1038/bjc.1995.387

M3 - Article

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AN - SCOPUS:0029134548

SN - 0007-0920

VL - 72

SP - 642

EP - 645

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

Microsatellite instability in human testicular germ cell tumours

Abstract

UN SDGs

Keywords

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