Modeling cardiovascular disease in the zebrafish

Timothy J. A. Chico, Philip W. Ingham, David C. Crossman

Research output: Contribution to journalArticle

111 Citations (Scopus)


The zebrafish possesses a host of advantages that have established it as an excellent model of vertebrate development. These include ease of genetic manipulation and transgenesis, optical clarity, and small size and cost. Biomedical researchers are increasingly exploiting these advantages to model human disease mechanisms. Here we review the use of the zebrafish for cardiovascular research. We summarize previous studies with the use of this organism to model such processes as thrombosis, collateral vessel development, inflammation, cardiomyopathy, and cardiac regeneration, evaluate its promise for novel drug discovery, and consider where the zebrafish fits into the framework of existing cardiovascular models.
Original languageEnglish
Pages (from-to)150-155
Number of pages6
JournalTrends in Cardiovascular Medicine
Issue number4
Publication statusPublished - May 2008

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