Modulation of the natriuretic peptide system in heart failure: from bench to bedside?

Matthias Schmitt, John R Cockcroft, Michael P Frenneaux

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Since the discovery of atrial natriuretic peptide, the unravelling of the natriuretic peptide system has been a story of scientific success. However, bridging the gap between bench and bedside has proved difficult, and as yet has not provided any major clinical progress. In this review we will first give a detailed outline of the key elements constituting the natriuretic peptide system. Secondly, we will briefly explain the underlying rationale, basic concepts and evidence behind currently pursued strategies to potentiate the natriuretic peptide system. Thirdly, we will highlight some of the problems that have so far hindered successful translation of these theoretically viable treatment options into tangible clinical progress.
Original languageEnglish
Pages (from-to)141-60
Number of pages20
JournalClinical Science
Issue number2
Publication statusPublished - Aug 2003


  • Animals
  • Atrial Natriuretic Factor
  • Cardiotonic Agents
  • Heart Failure
  • Humans
  • Mice
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Peptide Hormones

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