Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India

Satheesh Nair; Madhulika Unnikrishnan; Keith Turner; Subash Chandra Parija; Carol Churcher; John Wain; Belgode Narasimha Harish

doi:10.3201/eid1203.050560

Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India

Satheesh Nair, Madhulika Unnikrishnan, Keith Turner, Subash Chandra Parija, Carol Churcher, John Wain, Belgode Narasimha Harish

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).

Original language	English
Pages (from-to)	489-491
Number of pages	3
Journal	Emerging Infectious Diseases
Volume	12
Issue number	3
DOIs	https://doi.org/10.3201/eid1203.050560
Publication status	Published - Mar 2006

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10.3201/eid1203.050560

Cite this

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title = "Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India",

abstract = "Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).",

author = "Satheesh Nair and Madhulika Unnikrishnan and Keith Turner and Parija, {Subash Chandra} and Carol Churcher and John Wain and Harish, {Belgode Narasimha}",

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AU - Nair, Satheesh

AU - Unnikrishnan, Madhulika

AU - Turner, Keith

AU - Parija, Subash Chandra

AU - Churcher, Carol

AU - Wain, John

AU - Harish, Belgode Narasimha

PY - 2006/3

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N2 - Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).

AB - Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).

U2 - 10.3201/eid1203.050560

DO - 10.3201/eid1203.050560

M3 - Article

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EP - 491

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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