Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India

Satheesh Nair; Madhulika Unnikrishnan; Keith Turner; Subash Chandra Parija; Carol Churcher; John Wain; Belgode Narasimha Harish

doi:10.3201/eid1203.050560

Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India

Satheesh Nair
, Madhulika Unnikrishnan
, Keith Turner
, Subash Chandra Parija
, Carol Churcher
, John Wain
, Belgode Narasimha Harish

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).

Original language	English
Pages (from-to)	489-491
Number of pages	3
Journal	Emerging Infectious Diseases
Volume	12
Issue number	3
DOIs	https://doi.org/10.3201/eid1203.050560
Publication status	Published - Mar 2006

Access to Document

10.3201/eid1203.050560

Cite this

@article{ff2ba1f8ec614cc28b94dccb0ae802a2,

title = "Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India",

abstract = "Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).",

author = "Satheesh Nair and Madhulika Unnikrishnan and Keith Turner and Parija, \{Subash Chandra\} and Carol Churcher and John Wain and Harish, \{Belgode Narasimha\}",

year = "2006",

month = mar,

doi = "10.3201/eid1203.050560",

language = "English",

volume = "12",

pages = "489--491",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "3",

}

TY - JOUR

T1 - Molecular analysis of fluoroquinolone-resistant Salmonella Paratyphi A isolate, India

AU - Nair, Satheesh

AU - Unnikrishnan, Madhulika

AU - Turner, Keith

AU - Parija, Subash Chandra

AU - Churcher, Carol

AU - Wain, John

AU - Harish, Belgode Narasimha

PY - 2006/3

Y1 - 2006/3

N2 - Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).

AB - Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83-->Phe and Asp87-->Gly) and a mutation in topoisomerase IV subunit parC (Ser80-->Arg).

U2 - 10.3201/eid1203.050560

DO - 10.3201/eid1203.050560

M3 - Article

SN - 1080-6040

VL - 12

SP - 489

EP - 491

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 3

ER -