Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

A H M Reid, G Attard, L Ambroisine, G Fisher, G Kovacs, D Brewer, J Clark, P Flohr, S Edwards, D M Berney, C S Foster, A Fletcher, W L Gerald, H Møller, V E Reuter, P T Scardino, J Cuzick, J S de Bono, C S Cooper, Transatlantic Prostate Group

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215 Citations (Scopus)

Abstract

The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.
Original languageEnglish
Pages (from-to)678-684
Number of pages7
JournalBritish Journal of Cancer
Volume102
Issue number4
DOIs
Publication statusPublished - 16 Feb 2010

Keywords

  • Aged
  • Carcinoma
  • Cause of Death
  • Cohort Studies
  • DNA Mutational Analysis
  • DNA-Binding Proteins
  • Genetic Loci
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Middle Aged
  • Models, Biological
  • PTEN Phosphohydrolase
  • Prognosis
  • Prostatic Neoplasms
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Tissue Array Analysis
  • Trans-Activators
  • Transcription Factors

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