Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

A H M Reid; G Attard; L Ambroisine; G Fisher; G Kovacs; D Brewer; J Clark; P Flohr; S Edwards; D M Berney; C S Foster; A Fletcher; W L Gerald; H Møller; V E Reuter; P T Scardino; J Cuzick; J S de Bono; C S Cooper; Transatlantic Prostate Group

doi:10.1038/sj.bjc.6605554

Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

A H M Reid, G Attard, L Ambroisine, G Fisher, G Kovacs, D Brewer, J Clark, P Flohr, S Edwards, D M Berney, C S Foster, A Fletcher, W L Gerald, H Møller, V E Reuter, P T Scardino, J Cuzick, J S de Bono, C S Cooper, Transatlantic Prostate Group

Research output: Contribution to journal › Article › peer-review

236 Citations (Scopus)

Abstract

The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.

Original language	English
Pages (from-to)	678-684
Number of pages	7
Journal	British Journal of Cancer
Volume	102
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6605554
Publication status	Published - 16 Feb 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aged
Carcinoma
Cause of Death
Cohort Studies
DNA Mutational Analysis
DNA-Binding Proteins
Genetic Loci
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Models, Biological
PTEN Phosphohydrolase
Prognosis
Prostatic Neoplasms
Retrospective Studies
Risk Factors
Survival Analysis
Tissue Array Analysis
Trans-Activators
Transcription Factors

Access to Document

10.1038/sj.bjc.6605554Licence: CC BY-NC-SA

Cite this

Reid, A. H. M., Attard, G., Ambroisine, L., Fisher, G., Kovacs, G., Brewer, D., Clark, J., Flohr, P., Edwards, S., Berney, D. M., Foster, C. S., Fletcher, A., Gerald, W. L., Møller, H., Reuter, V. E., Scardino, P. T., Cuzick, J., de Bono, J. S., Cooper, C. S., & Transatlantic Prostate Group (2010). Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. British Journal of Cancer, 102(4), 678-684. https://doi.org/10.1038/sj.bjc.6605554

@article{08269538780e472bacfcb1dbf72a5b0d,

title = "Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer",

abstract = "The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.",

keywords = "Aged, Carcinoma, Cause of Death, Cohort Studies, DNA Mutational Analysis, DNA-Binding Proteins, Genetic Loci, Humans, In Situ Hybridization, Fluorescence, Male, Middle Aged, Models, Biological, PTEN Phosphohydrolase, Prognosis, Prostatic Neoplasms, Retrospective Studies, Risk Factors, Survival Analysis, Tissue Array Analysis, Trans-Activators, Transcription Factors",

author = "Reid, {A H M} and G Attard and L Ambroisine and G Fisher and G Kovacs and D Brewer and J Clark and P Flohr and S Edwards and Berney, {D M} and Foster, {C S} and A Fletcher and Gerald, {W L} and H M{\o}ller and Reuter, {V E} and Scardino, {P T} and J Cuzick and {de Bono}, {J S} and Cooper, {C S} and {Transatlantic Prostate Group}",

year = "2010",

month = feb,

day = "16",

doi = "10.1038/sj.bjc.6605554",

language = "English",

volume = "102",

pages = "678--684",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Nature Publishing Group",

number = "4",

}

Reid, AHM, Attard, G, Ambroisine, L, Fisher, G, Kovacs, G, Brewer, D , Clark, J, Flohr, P, Edwards, S, Berney, DM, Foster, CS, Fletcher, A, Gerald, WL, Møller, H, Reuter, VE, Scardino, PT, Cuzick, J, de Bono, JS, Cooper, CS & Transatlantic Prostate Group 2010, 'Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer', British Journal of Cancer, vol. 102, no. 4, pp. 678-684. https://doi.org/10.1038/sj.bjc.6605554

TY - JOUR

T1 - Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer

AU - Reid, A H M

AU - Attard, G

AU - Ambroisine, L

AU - Fisher, G

AU - Kovacs, G

AU - Brewer, D

AU - Clark, J

AU - Flohr, P

AU - Edwards, S

AU - Berney, D M

AU - Foster, C S

AU - Fletcher, A

AU - Gerald, W L

AU - Møller, H

AU - Reuter, V E

AU - Scardino, P T

AU - Cuzick, J

AU - de Bono, J S

AU - Cooper, C S

AU - Transatlantic Prostate Group

PY - 2010/2/16

Y1 - 2010/2/16

N2 - The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.

AB - The discovery of ERG/ETV1 gene rearrangements and PTEN gene loss warrants investigation in a mechanism-based prognostic classification of prostate cancer (PCa). The study objective was to evaluate the potential clinical significance and natural history of different disease categories by combining ERG/ETV1 gene rearrangements and PTEN gene loss status.

KW - Aged

KW - Carcinoma

KW - Cause of Death

KW - Cohort Studies

KW - DNA Mutational Analysis

KW - DNA-Binding Proteins

KW - Genetic Loci

KW - Humans

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Middle Aged

KW - Models, Biological

KW - PTEN Phosphohydrolase

KW - Prognosis

KW - Prostatic Neoplasms

KW - Retrospective Studies

KW - Risk Factors

KW - Survival Analysis

KW - Tissue Array Analysis

KW - Trans-Activators

KW - Transcription Factors

U2 - 10.1038/sj.bjc.6605554

DO - 10.1038/sj.bjc.6605554

M3 - Article

C2 - 20104229

SN - 0007-0920

VL - 102

SP - 678

EP - 684

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -