Molecular genetics of soft tissue sarcomas

Colin S. Cooper, Paul Cornes

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


During the past decade considerable progress has been made in elucidating the mechanisms underlying the development of human soft tissue sarcomas. It has been established that certain genetic disorders can predispose to the development of soft tissue sarcomas, and in many cases the individual genes containing the inherited mutation have been cloned and characterized. Cytogenetic studies have identified specific chromosomal translocations in certain types of soft tissue sarcoma, and most of the genes that become altered by these rearrangements have now been isolated. Progress has also been made in identifying genes that control the differentiation of some mesenchymal lineage (e.g., striated muscle). These recent developments are reviewed in this chapter, with particular emphasis being placed on (1) recent advances that have been made in understanding precisely how the genetic alteration found in soft tissue sarcomas may lead to tumor formation and (2) the potential use of genetic markers in tumor diagnosis and prognosis.
Original languageEnglish
Title of host publicationSoft Tissue Sarcomas
Subtitle of host publicationPresent Achievements and Future Prospects
EditorsJ. Verweij, H. M. Pinedo, H. D. Suit
Place of PublicationBoston, MA
Number of pages20
ISBN (Electronic)978-1-4615-6121-7
ISBN (Print)978-1-4613-7805-1
Publication statusPublished - 1997

Publication series

NameCancer Treatment and Research
ISSN (Print)0927-3042

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