Molecular mechanisms of antibiotic resistance

Jessica M A Blair, Mark A. Webber, Alison J. Baylay, David O. Ogbolu, Laura J V Piddock

Research output: Contribution to journalReview articlepeer-review

2582 Citations (Scopus)


Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

Original languageEnglish
Pages (from-to)42-51
Number of pages10
JournalNature Reviews Microbiology
Issue number1
Early online date1 Dec 2014
Publication statusPublished - Jan 2015
Externally publishedYes

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