TY - JOUR
T1 - Molecular mechanisms of antibiotic resistance revisited
AU - Darby, Elizabeth M.
AU - Trampari, Eleftheria
AU - Siasat, Pauline
AU - Gaya, Maria Solsona
AU - Alav, Ilyas
AU - Webber, Mark A.
AU - Blair, Jessica M.A.
N1 - Publisher Copyright:
© 2022, Springer Nature Limited.
PY - 2023/5
Y1 - 2023/5
N2 - Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.
AB - Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics currently in clinical use and only a few novel drugs in the pipeline. Understanding the molecular mechanisms that bacteria use to resist the action of antimicrobials is critical to recognize global patterns of resistance and to improve the use of current drugs, as well as for the design of new drugs less susceptible to resistance development and novel strategies to combat resistance. In this Review, we explore recent advances in understanding how resistance genes contribute to the biology of the host, new structural details of relevant molecular events underpinning resistance, the identification of new resistance gene families and the interactions between different resistance mechanisms. Finally, we discuss how we can use this information to develop the next generation of antimicrobial therapies.
UR - http://www.scopus.com/inward/record.url?scp=85142245031&partnerID=8YFLogxK
U2 - 10.1038/s41579-022-00820-y
DO - 10.1038/s41579-022-00820-y
M3 - Review article
C2 - 36411397
AN - SCOPUS:85142245031
VL - 21
SP - 280
EP - 295
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
SN - 1740-1526
IS - 5
ER -
