Molecular mechanisms of early plant pattern-triggered immune signaling

Thomas A. DeFalco, Cyril Zipfel

Research output: Contribution to journalArticlepeer-review

150 Citations (Scopus)


All eukaryotic organisms have evolved sophisticated immune systems to appropriately respond to biotic stresses. In plants and animals, a key part of this immune system is pattern recognition receptors (PRRs). Plant PRRs are cell-surface-localized receptor kinases (RKs) or receptor proteins (RPs) that sense microbe- or self-derived molecular patterns to regulate pattern-triggered immunity (PTI), a robust form of antimicrobial immunity. Remarkable progress has been made in understanding how PRRs perceive their ligands, form active protein complexes, initiate cell signaling, and ultimately coordinate the cellular reprogramming that leads to PTI. Here, we discuss the critical roles of PRR complex formation and phosphorylation in activating PTI signaling, as well as the emerging paradigm in which receptor-like cytoplasmic kinases (RLCKs) act as executors of signaling downstream of PRR activation.
Original languageEnglish
Pages (from-to)3449-3467
Number of pages19
JournalMolecular Cell
Issue number17
Early online date16 Aug 2021
Publication statusPublished - 2 Sep 2021

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