Molecular Similarity of MDR Inhibitors

Mire Zloh, Simon Gibbons

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The molecular similarity of multidrug resistance (MDR) inhibitors was evaluated using the point centred atom charge approach in an attempt to find some common features of structurally unrelated inhibitors. A series of inhibitors of bacterial MDR were studied and there is a high similarity between these in terms of their shape, presence and orientation of aromatic ring moieties. A comparison of the lipophilic properties of these molecules has also been conducted suggesting that this factor is important in MDR inhibition.
Original languageEnglish
Pages (from-to)37-47
Number of pages11
JournalInternational Journal of Molecular Sciences
Volume5
Issue number2
DOIs
Publication statusPublished - 30 Jan 2004

Cite this