Monitoring vaccine safety using case series cumulative sum charts

Patrick Musonda, Mounia N. Hocine, Nick J. Andrews, Pascale Tubert-Bitter, C. Paddy Farrington

Research output: Contribution to journalArticle

17 Citations (Scopus)


We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.
Original languageEnglish
Pages (from-to)5358-5367
Number of pages10
Issue number42
Publication statusPublished - 2008

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