Monitoring vaccine safety using case series cumulative sum charts

Patrick Musonda; Mounia N. Hocine; Nick J. Andrews; Pascale Tubert-Bitter; C. Paddy Farrington

doi:10.1016/j.vaccine.2008.08.010

Monitoring vaccine safety using case series cumulative sum charts

Patrick Musonda, Mounia N. Hocine, Nick J. Andrews, Pascale Tubert-Bitter, C. Paddy Farrington

Norwich Medical School

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.

Original language	English
Pages (from-to)	5358-5367
Number of pages	10
Journal	Vaccine
Volume	26
Issue number	42
DOIs	https://doi.org/10.1016/j.vaccine.2008.08.010
Publication status	Published - 2008

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10.1016/j.vaccine.2008.08.010

Cite this

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title = "Monitoring vaccine safety using case series cumulative sum charts",

abstract = "We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.",

author = "Patrick Musonda and Hocine, {Mounia N.} and Andrews, {Nick J.} and Pascale Tubert-Bitter and Farrington, {C. Paddy}",

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T1 - Monitoring vaccine safety using case series cumulative sum charts

AU - Musonda, Patrick

AU - Hocine, Mounia N.

AU - Andrews, Nick J.

AU - Tubert-Bitter, Pascale

AU - Farrington, C. Paddy

PY - 2008

Y1 - 2008

N2 - We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.

AB - We adapt the self-controlled case series method for routine surveillance of vaccine safety using cumulative sum (CUSUM) charts. The CUSUM surveillance method we propose is applicable for detecting associations that arise in a short pre-determined risk period following vaccination. The performance of the case series CUSUM is investigated through simulations. We illustrate the method using retrospective analyses of influenza vaccine and Bell's palsy, and MMR vaccine and febrile convulsions.

U2 - 10.1016/j.vaccine.2008.08.010

DO - 10.1016/j.vaccine.2008.08.010

M3 - Article

VL - 26

SP - 5358

EP - 5367

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 42

ER -