Mono- and dinuclear (η6-arene) ruthenium(II) benzaldehyde thiosemicarbazone complexes: Synthesis, characterization and cytotoxicity

Tameryn Stringer, Bruno Therrien, Denver T. Hendricks, Hajira Guzgay, Gregory S. Smith

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


A series of mono- and dinuclear (η6-arene) ruthenium(II) complexes were prepared by reaction of thiosemicarbazone ligands derived from benzaldehyde and ruthenium(II) precursors of the general formula [Ru(η6-arene)(μ-Cl)Cl]2, where arene = p-iPrC6H4Me or C6H5C3H6COOH. These complexes were characterized by NMR and IR spectroscopy, ESI-mass spectrometry and elemental analysis. The molecular structure of the mononuclear p-cymene complex was determined by X-ray diffraction analysis, revealing a pseudo-tetrahedral piano stool conformation and a bidentate N,S coordination mode of the thiosemicarbazone ligand. The complexes and ligands were evaluated for their in vitro cytotoxicity against the WHCO1 oesophageal cancer cell line.
Original languageEnglish
Pages (from-to)956-960
Number of pages5
JournalInorganic Chemistry Communications
Issue number6
Early online date24 Mar 2011
Publication statusPublished - Jun 2011

Cite this