MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie

Yuen Li Chung; Alun Williams; John S. Beech; Steve C.R. Williams; Jimmy D. Bell; Jane I. Cox; James Hope

doi:10.1006/neur.1995.0025

MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie

Yuen Li Chung, Alun Williams, John S. Beech, Steve C.R. Williams, Jimmy D. Bell, Jane I. Cox, James Hope

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.

Original language	English
Pages (from-to)	203-207
Number of pages	5
Journal	Neurodegeneration
Volume	4
Issue number	2
DOIs	https://doi.org/10.1006/neur.1995.0025
Publication status	Published - Jun 1995

Keywords

Blood-brain barrier
Gd-DTPA
Hamster model (263K)
Proton nuclear magnetic resonance imaging
Scrapie

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10.1006/neur.1995.0025

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title = "MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie",

abstract = "Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.",

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AU - Bell, Jimmy D.

AU - Cox, Jane I.

AU - Hope, James

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AB - Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.

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MRI Assessment of the Blood-Brain Barrier in a Hamster Model of Scrapie

Abstract

Keywords

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