Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers

Joseph L. Jorizzo; John L. Abernethy; Wain L. White; Heidi C. Mangelsdorf; Christos C. Zouboulis; Rifkiye Sarica; Karl Gaffney; Cem Mat; Hasan Yazici; Abdullah al Ialaan; Samir Helmy Assad-Khali; Fumio Kaneko; Ernest A. Frederick Jorizzo

doi:10.1016/0190-9622(95)91333-5

Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers

Joseph L. Jorizzo, John L. Abernethy, Wain L. White, Heidi C. Mangelsdorf, Christos C. Zouboulis, Rifkiye Sarica, Karl Gaffney, Cem Mat, Hasan Yazici, Abdullah al Ialaan, Samir Helmy Assad-Khali, Fumio Kaneko, Ernest A. Frederick Jorizzo

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

BACKGROUND: Although four of five of the new international criteria for the diagnosis of Behçet's disease relate to mucocutaneous lesions, disagreement exists as to the exact nature of cutaneous lesions (e.g., vessel-based vs follicular).

OBJECTIVE: Our purpose was to review clinical data, clinical photographs, and skin biopsy specimens from multiple medical centers throughout the world to monitor current practice in the implementation of mucocutaneous diagnostic criteria for Behçet's disease.

METHODS: Ten medical centers responded to a request to collaborate by sending clinical data, photographs of cutaneous lesions, and biopsy specimens from 22 patients.

RESULTS: Of specimens from 22 patients, 14 revealed a histopathologic pattern of neutrophils containing perivascular and interstitial inflammation, whereas specimens from three patients revealed only mononuclear cells in a vessel-based pattern. Biopsy specimens from three patients revealed primarily folliculocentric inflammation and an additional two specimens were from erythema nodosum-like lesions.

CONCLUSION: Perivascular inflammation was the predominant histopathologic finding in specimens of cutaneous lesions in this clinical series. Folliculocentric lesions could not be predicted on the basis of review of clinical photographs. Histopathologic assessment of cutaneous lesions is crucial if the proposal is accepted that exclusion of folliculocentric lesions is important to ensure accurate implementation of diagnostic criteria in patients with suspected Behçet's disease.

Original language	English
Pages (from-to)	968-976
Number of pages	9
Journal	Journal of the American Academy of Dermatology
Volume	32
Issue number	6
DOIs	https://doi.org/10.1016/0190-9622(95)91333-5
Publication status	Published - 1 Jun 1995

Keywords

Adult
Behcet Syndrome/diagnosis
Female
Humans
Male
Middle Aged
Mucous Membrane/pathology
Skin/pathology

Access to Document

10.1016/0190-9622(95)91333-5

Cite this

Jorizzo, J. L., Abernethy, J. L., White, W. L., Mangelsdorf, H. C., Zouboulis, C. C., Sarica, R., Gaffney, K., Mat, C., Yazici, H., al Ialaan, A., Assad-Khali, S. H., Kaneko, F., & Jorizzo, E. A. F. (1995). Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers. Journal of the American Academy of Dermatology, 32(6), 968-976. https://doi.org/10.1016/0190-9622(95)91333-5

@article{545c67ea267f4014be149c15cec3283e,

title = "Mucocutaneous criteria for the diagnosis of Beh{\c c}et's disease: an analysis of clinicopathologic data from multiple international centers",

abstract = "BACKGROUND: Although four of five of the new international criteria for the diagnosis of Beh{\c c}et's disease relate to mucocutaneous lesions, disagreement exists as to the exact nature of cutaneous lesions (e.g., vessel-based vs follicular).OBJECTIVE: Our purpose was to review clinical data, clinical photographs, and skin biopsy specimens from multiple medical centers throughout the world to monitor current practice in the implementation of mucocutaneous diagnostic criteria for Beh{\c c}et's disease.METHODS: Ten medical centers responded to a request to collaborate by sending clinical data, photographs of cutaneous lesions, and biopsy specimens from 22 patients.RESULTS: Of specimens from 22 patients, 14 revealed a histopathologic pattern of neutrophils containing perivascular and interstitial inflammation, whereas specimens from three patients revealed only mononuclear cells in a vessel-based pattern. Biopsy specimens from three patients revealed primarily folliculocentric inflammation and an additional two specimens were from erythema nodosum-like lesions.CONCLUSION: Perivascular inflammation was the predominant histopathologic finding in specimens of cutaneous lesions in this clinical series. Folliculocentric lesions could not be predicted on the basis of review of clinical photographs. Histopathologic assessment of cutaneous lesions is crucial if the proposal is accepted that exclusion of folliculocentric lesions is important to ensure accurate implementation of diagnostic criteria in patients with suspected Beh{\c c}et's disease.",

keywords = "Adult, Behcet Syndrome/diagnosis, Female, Humans, Male, Middle Aged, Mucous Membrane/pathology, Skin/pathology",

author = "Jorizzo, {Joseph L.} and Abernethy, {John L.} and White, {Wain L.} and Mangelsdorf, {Heidi C.} and Zouboulis, {Christos C.} and Rifkiye Sarica and Karl Gaffney and Cem Mat and Hasan Yazici and {al Ialaan}, Abdullah and Assad-Khali, {Samir Helmy} and Fumio Kaneko and Jorizzo, {Ernest A. Frederick}",

year = "1995",

month = jun,

day = "1",

doi = "10.1016/0190-9622(95)91333-5",

language = "English",

volume = "32",

pages = "968--976",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby Inc.",

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Jorizzo, JL, Abernethy, JL, White, WL, Mangelsdorf, HC, Zouboulis, CC, Sarica, R, Gaffney, K, Mat, C, Yazici, H, al Ialaan, A, Assad-Khali, SH, Kaneko, F & Jorizzo, EAF 1995, 'Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers', Journal of the American Academy of Dermatology, vol. 32, no. 6, pp. 968-976. https://doi.org/10.1016/0190-9622(95)91333-5

TY - JOUR

T1 - Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers

AU - Jorizzo, Joseph L.

AU - Abernethy, John L.

AU - White, Wain L.

AU - Mangelsdorf, Heidi C.

AU - Zouboulis, Christos C.

AU - Sarica, Rifkiye

AU - Gaffney, Karl

AU - Mat, Cem

AU - Yazici, Hasan

AU - al Ialaan, Abdullah

AU - Assad-Khali, Samir Helmy

AU - Kaneko, Fumio

AU - Jorizzo, Ernest A. Frederick

PY - 1995/6/1

Y1 - 1995/6/1

N2 - BACKGROUND: Although four of five of the new international criteria for the diagnosis of Behçet's disease relate to mucocutaneous lesions, disagreement exists as to the exact nature of cutaneous lesions (e.g., vessel-based vs follicular).OBJECTIVE: Our purpose was to review clinical data, clinical photographs, and skin biopsy specimens from multiple medical centers throughout the world to monitor current practice in the implementation of mucocutaneous diagnostic criteria for Behçet's disease.METHODS: Ten medical centers responded to a request to collaborate by sending clinical data, photographs of cutaneous lesions, and biopsy specimens from 22 patients.RESULTS: Of specimens from 22 patients, 14 revealed a histopathologic pattern of neutrophils containing perivascular and interstitial inflammation, whereas specimens from three patients revealed only mononuclear cells in a vessel-based pattern. Biopsy specimens from three patients revealed primarily folliculocentric inflammation and an additional two specimens were from erythema nodosum-like lesions.CONCLUSION: Perivascular inflammation was the predominant histopathologic finding in specimens of cutaneous lesions in this clinical series. Folliculocentric lesions could not be predicted on the basis of review of clinical photographs. Histopathologic assessment of cutaneous lesions is crucial if the proposal is accepted that exclusion of folliculocentric lesions is important to ensure accurate implementation of diagnostic criteria in patients with suspected Behçet's disease.

AB - BACKGROUND: Although four of five of the new international criteria for the diagnosis of Behçet's disease relate to mucocutaneous lesions, disagreement exists as to the exact nature of cutaneous lesions (e.g., vessel-based vs follicular).OBJECTIVE: Our purpose was to review clinical data, clinical photographs, and skin biopsy specimens from multiple medical centers throughout the world to monitor current practice in the implementation of mucocutaneous diagnostic criteria for Behçet's disease.METHODS: Ten medical centers responded to a request to collaborate by sending clinical data, photographs of cutaneous lesions, and biopsy specimens from 22 patients.RESULTS: Of specimens from 22 patients, 14 revealed a histopathologic pattern of neutrophils containing perivascular and interstitial inflammation, whereas specimens from three patients revealed only mononuclear cells in a vessel-based pattern. Biopsy specimens from three patients revealed primarily folliculocentric inflammation and an additional two specimens were from erythema nodosum-like lesions.CONCLUSION: Perivascular inflammation was the predominant histopathologic finding in specimens of cutaneous lesions in this clinical series. Folliculocentric lesions could not be predicted on the basis of review of clinical photographs. Histopathologic assessment of cutaneous lesions is crucial if the proposal is accepted that exclusion of folliculocentric lesions is important to ensure accurate implementation of diagnostic criteria in patients with suspected Behçet's disease.

KW - Adult

KW - Behcet Syndrome/diagnosis

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Mucous Membrane/pathology

KW - Skin/pathology

U2 - 10.1016/0190-9622(95)91333-5

DO - 10.1016/0190-9622(95)91333-5

M3 - Article

C2 - 7751467

VL - 32

SP - 968

EP - 976

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 6

ER -