Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis

Ian M Balfour-Lynn, Belinda Lees, Pippa Hall, Gillian Phillips, Mohammed Khan, Marcus Flather, J Stuart Elborn, CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators

Research output: Contribution to journalArticlepeer-review

136 Citations (Scopus)


Lung inflammation and injury is critical in cystic fibrosis. An ideal antiinflammatory agent has not been identified but inhaled corticosteroids are widely used despite lack of evidence.
Original languageEnglish
Pages (from-to)1356-62
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number12
Publication statusPublished - 15 Jun 2006


  • Administration, Inhalation
  • Adolescent
  • Adrenal Cortex Hormones
  • Adult
  • Age Factors
  • Androstadienes
  • Anti-Inflammatory Agents
  • Asthma
  • Bronchodilator Agents
  • Child
  • Cystic Fibrosis
  • Double-Blind Method
  • Feasibility Studies
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Humans
  • Lung
  • Male
  • Middle Aged
  • Placebos
  • Pseudomonas aeruginosa
  • Safety
  • Withholding Treatment

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