Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis

Ian M Balfour-Lynn; Belinda Lees; Pippa Hall; Gillian Phillips; Mohammed Khan; Marcus Flather; J Stuart Elborn; CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators

doi:10.1164/rccm.200511-1808OC

Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis

Ian M Balfour-Lynn, Belinda Lees, Pippa Hall, Gillian Phillips, Mohammed Khan, Marcus Flather, J Stuart Elborn, CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators

Research output: Contribution to journal › Article › peer-review

138 Citations (Scopus)

Abstract

Lung inflammation and injury is critical in cystic fibrosis. An ideal antiinflammatory agent has not been identified but inhaled corticosteroids are widely used despite lack of evidence.

Original language	English
Pages (from-to)	1356-62
Number of pages	7
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	173
Issue number	12
DOIs	https://doi.org/10.1164/rccm.200511-1808OC
Publication status	Published - 15 Jun 2006

Keywords

Administration, Inhalation
Adolescent
Adrenal Cortex Hormones
Adult
Age Factors
Androstadienes
Anti-Inflammatory Agents
Asthma
Bronchodilator Agents
Child
Cystic Fibrosis
Double-Blind Method
Feasibility Studies
Female
Follow-Up Studies
Forced Expiratory Volume
Humans
Lung
Male
Middle Aged
Placebos
Pseudomonas aeruginosa
Safety
Withholding Treatment

Access to Document

10.1164/rccm.200511-1808OC

Cite this

Balfour-Lynn, I. M., Lees, B., Hall, P., Phillips, G., Khan, M., Flather, M., Elborn, J. S., & CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators (2006). Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine, 173(12), 1356-62. https://doi.org/10.1164/rccm.200511-1808OC

Balfour-Lynn, Ian M ; Lees, Belinda ; Hall, Pippa ; Phillips, Gillian ; Khan, Mohammed ; Flather, Marcus ; Elborn, J Stuart ; CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators. / Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis. In: American Journal of Respiratory and Critical Care Medicine. 2006 ; Vol. 173, No. 12. pp. 1356-62.

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title = "Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis",

abstract = "Lung inflammation and injury is critical in cystic fibrosis. An ideal antiinflammatory agent has not been identified but inhaled corticosteroids are widely used despite lack of evidence.",

keywords = "Administration, Inhalation, Adolescent, Adrenal Cortex Hormones, Adult, Age Factors, Androstadienes, Anti-Inflammatory Agents, Asthma, Bronchodilator Agents, Child, Cystic Fibrosis, Double-Blind Method, Feasibility Studies, Female, Follow-Up Studies, Forced Expiratory Volume, Humans, Lung, Male, Middle Aged, Placebos, Pseudomonas aeruginosa, Safety, Withholding Treatment",

author = "Balfour-Lynn, {Ian M} and Belinda Lees and Pippa Hall and Gillian Phillips and Mohammed Khan and Marcus Flather and Elborn, {J Stuart} and {CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators}",

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doi = "10.1164/rccm.200511-1808OC",

language = "English",

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Balfour-Lynn, IM, Lees, B, Hall, P, Phillips, G, Khan, M, Flather, M, Elborn, JS & CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators 2006, 'Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis', American Journal of Respiratory and Critical Care Medicine, vol. 173, no. 12, pp. 1356-62. https://doi.org/10.1164/rccm.200511-1808OC

Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis. / Balfour-Lynn, Ian M; Lees, Belinda; Hall, Pippa; Phillips, Gillian; Khan, Mohammed; Flather, Marcus; Elborn, J Stuart; CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 173, No. 12, 15.06.2006, p. 1356-62.

Research output: Contribution to journal › Article › peer-review

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AU - Balfour-Lynn, Ian M

AU - Lees, Belinda

AU - Hall, Pippa

AU - Phillips, Gillian

AU - Khan, Mohammed

AU - Flather, Marcus

AU - Elborn, J Stuart

AU - CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators

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KW - Age Factors

KW - Androstadienes

KW - Anti-Inflammatory Agents

KW - Asthma

KW - Bronchodilator Agents

KW - Child

KW - Cystic Fibrosis

KW - Double-Blind Method

KW - Feasibility Studies

KW - Female

KW - Follow-Up Studies

KW - Forced Expiratory Volume

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KW - Lung

KW - Male

KW - Middle Aged

KW - Placebos

KW - Pseudomonas aeruginosa

KW - Safety

KW - Withholding Treatment

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