Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Brian Harding; Manuel C. Lemos; Anita A. C. Reed; Gerard V. Walls; Jeshmi Jeyabalan; Michael R Bowl; Hilda Tateossian; Nicky Sullivan; Tertius Hough; William D. Fraser; Olaf Ansorge; Michael T. Cheeseman; Rajesh V. Thakker

doi:10.1677/ERC-09-0082

Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Brian Harding, Manuel C. Lemos, Anita A. C. Reed, Gerard V. Walls, Jeshmi Jeyabalan, Michael R Bowl, Hilda Tateossian, Nicky Sullivan, Tertius Hough, William D. Fraser, Olaf Ansorge, Michael T. Cheeseman, Rajesh V. Thakker

Research output: Contribution to journal › Article

80 Citations (Scopus)

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (

Original language	English
Pages (from-to)	1313-1327
Number of pages	15
Journal	Endocrine-Related Cancer (ERC)
Volume	16
Issue number	4
DOIs	https://doi.org/10.1677/ERC-09-0082
Publication status	Published - 2009

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10.1677/ERC-09-0082

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Harding, B., Lemos, M. C., Reed, A. A. C., Walls, G. V., Jeyabalan, J., Bowl, M. R., Tateossian, H., Sullivan, N., Hough, T., Fraser, W. D., Ansorge, O., Cheeseman, M. T., & Thakker, R. V. (2009). Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Endocrine-Related Cancer (ERC), 16(4), 1313-1327. https://doi.org/10.1677/ERC-09-0082

Harding, Brian ; Lemos, Manuel C. ; Reed, Anita A. C. ; Walls, Gerard V. ; Jeyabalan, Jeshmi ; Bowl, Michael R ; Tateossian, Hilda ; Sullivan, Nicky ; Hough, Tertius ; Fraser, William D. ; Ansorge, Olaf ; Cheeseman, Michael T. ; Thakker, Rajesh V. / Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. In: Endocrine-Related Cancer (ERC). 2009 ; Vol. 16, No. 4. pp. 1313-1327.

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title = "Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.",

abstract = "Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (",

author = "Brian Harding and Lemos, {Manuel C.} and Reed, {Anita A. C.} and Walls, {Gerard V.} and Jeshmi Jeyabalan and Bowl, {Michael R} and Hilda Tateossian and Nicky Sullivan and Tertius Hough and Fraser, {William D.} and Olaf Ansorge and Cheeseman, {Michael T.} and Thakker, {Rajesh V.}",

year = "2009",

doi = "10.1677/ERC-09-0082",

language = "English",

volume = "16",

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journal = "Endocrine-Related Cancer (ERC)",

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Harding, B, Lemos, MC, Reed, AAC, Walls, GV, Jeyabalan, J, Bowl, MR, Tateossian, H, Sullivan, N, Hough, T, Fraser, WD, Ansorge, O, Cheeseman, MT & Thakker, RV 2009, 'Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.', Endocrine-Related Cancer (ERC), vol. 16, no. 4, pp. 1313-1327. https://doi.org/10.1677/ERC-09-0082

Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. / Harding, Brian; Lemos, Manuel C.; Reed, Anita A. C.; Walls, Gerard V.; Jeyabalan, Jeshmi; Bowl, Michael R; Tateossian, Hilda; Sullivan, Nicky; Hough, Tertius; Fraser, William D.; Ansorge, Olaf; Cheeseman, Michael T.; Thakker, Rajesh V.

In: Endocrine-Related Cancer (ERC), Vol. 16, No. 4, 2009, p. 1313-1327.

Research output: Contribution to journal › Article

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AU - Thakker, Rajesh V.

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