Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Brian Harding, Manuel C. Lemos, Anita A. C. Reed, Gerard V. Walls, Jeshmi Jeyabalan, Michael R Bowl, Hilda Tateossian, Nicky Sullivan, Tertius Hough, William D. Fraser, Olaf Ansorge, Michael T. Cheeseman, Rajesh V. Thakker

Research output: Contribution to journalArticle

79 Citations (Scopus)


Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (
Original languageEnglish
Pages (from-to)1313-1327
Number of pages15
JournalEndocrine-Related Cancer (ERC)
Issue number4
Publication statusPublished - 2009

Cite this