Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Brian Harding; Manuel C. Lemos; Anita A. C. Reed; Gerard V. Walls; Jeshmi Jeyabalan; Michael R Bowl; Hilda Tateossian; Nicky Sullivan; Tertius Hough; William D. Fraser; Olaf Ansorge; Michael T. Cheeseman; Rajesh V. Thakker

doi:10.1677/ERC-09-0082

Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

Brian Harding
, Manuel C. Lemos
, Anita A. C. Reed
, Gerard V. Walls
, Jeshmi Jeyabalan
, Michael R Bowl
, Hilda Tateossian
, Nicky Sullivan
, Tertius Hough
, William D. Fraser
, Olaf Ansorge
, Michael T. Cheeseman
, Rajesh V. Thakker

Research output: Contribution to journal › Article

90 Citations (Scopus)

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (

Original language	English
Pages (from-to)	1313-1327
Number of pages	15
Journal	Endocrine-Related Cancer (ERC)
Volume	16
Issue number	4
DOIs	https://doi.org/10.1677/ERC-09-0082
Publication status	Published - 2009

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10.1677/ERC-09-0082

Cite this

Harding, B., Lemos, M. C., Reed, A. A. C., Walls, G. V., Jeyabalan, J., Bowl, M. R., Tateossian, H., Sullivan, N., Hough, T., Fraser, W. D., Ansorge, O., Cheeseman, M. T., & Thakker, R. V. (2009). Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia. Endocrine-Related Cancer (ERC), 16(4), 1313-1327. https://doi.org/10.1677/ERC-09-0082

@article{ca0861e0010d4d1bb9f5e8f951bd7129,

title = "Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.",

abstract = "Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (",

author = "Brian Harding and Lemos, \{Manuel C.\} and Reed, \{Anita A. C.\} and Walls, \{Gerard V.\} and Jeshmi Jeyabalan and Bowl, \{Michael R\} and Hilda Tateossian and Nicky Sullivan and Tertius Hough and Fraser, \{William D.\} and Olaf Ansorge and Cheeseman, \{Michael T.\} and Thakker, \{Rajesh V.\}",

year = "2009",

doi = "10.1677/ERC-09-0082",

language = "English",

volume = "16",

pages = "1313--1327",

journal = "Endocrine-Related Cancer (ERC)",

issn = "1351-0088",

publisher = "BioScientifica Ltd.",

number = "4",

}

Harding, B, Lemos, MC, Reed, AAC, Walls, GV, Jeyabalan, J, Bowl, MR, Tateossian, H, Sullivan, N, Hough, T, Fraser, WD, Ansorge, O, Cheeseman, MT & Thakker, RV 2009, 'Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.', Endocrine-Related Cancer (ERC), vol. 16, no. 4, pp. 1313-1327. https://doi.org/10.1677/ERC-09-0082

TY - JOUR

T1 - Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.

AU - Harding, Brian

AU - Lemos, Manuel C.

AU - Reed, Anita A. C.

AU - Walls, Gerard V.

AU - Jeyabalan, Jeshmi

AU - Bowl, Michael R

AU - Tateossian, Hilda

AU - Sullivan, Nicky

AU - Hough, Tertius

AU - Fraser, William D.

AU - Ansorge, Olaf

AU - Cheeseman, Michael T.

AU - Thakker, Rajesh V.

PY - 2009

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N2 - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (

AB - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice (

U2 - 10.1677/ERC-09-0082

DO - 10.1677/ERC-09-0082

M3 - Article

SN - 1351-0088

VL - 16

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JO - Endocrine-Related Cancer (ERC)

JF - Endocrine-Related Cancer (ERC)

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