Multiple introductions of multidrug-resistant tuberculosis into households, Lima, Peru

Ted Cohen; Megan B. Murray; Ibrahim Abubakar; Zibiao Zhang; Alexander Sloutsky; Fernando Arteaga; Katiuska Chalco; Molly F. Franke; Mercedes C. Becerra

doi:10.3201/eid1706.101471

Multiple introductions of multidrug-resistant tuberculosis into households, Lima, Peru

Ted Cohen, Megan B. Murray, Ibrahim Abubakar, Zibiao Zhang, Alexander Sloutsky, Fernando Arteaga, Katiuska Chalco, Molly F. Franke, Mercedes C. Becerra

Norwich Medical School

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the frequency of multiple introductions of MDR TB into households, we used spoligotyping and 24-loci mycobacterial interspersed repetitive unit- variable number tandem repeats to classify isolates from 101 households in Lima, Peru, in which >1 MDR TB patient received treatment during 1996-2004. We found different MDR TB strains in >10% of households. Alternate approaches for classifying matching strains produced estimates of multiple introductions in

Original language	English
Pages (from-to)	969-975
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	17
Issue number	6
DOIs	https://doi.org/10.3201/eid1706.101471
Publication status	Published - Jun 2011

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10.3201/eid1706.101471

Cite this

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abstract = "Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the frequency of multiple introductions of MDR TB into households, we used spoligotyping and 24-loci mycobacterial interspersed repetitive unit- variable number tandem repeats to classify isolates from 101 households in Lima, Peru, in which >1 MDR TB patient received treatment during 1996-2004. We found different MDR TB strains in >10% of households. Alternate approaches for classifying matching strains produced estimates of multiple introductions in ",

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AU - Cohen, Ted

AU - Murray, Megan B.

AU - Abubakar, Ibrahim

AU - Zhang, Zibiao

AU - Sloutsky, Alexander

AU - Arteaga, Fernando

AU - Chalco, Katiuska

AU - Franke, Molly F.

AU - Becerra, Mercedes C.

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