Multiple Introductions of Multidrug-Resistant Tuberculosis into Households, Lima, Peru

Ted Cohen, Megan B. Murray, Ibrahim Abubakar, Zibiao Zhang, Alexander Sloutsky, Fernando Arteaga, Katiuska Chalco, Molly F. Franke, Mercedes C. Becerra

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18 Citations (Scopus)

Abstract

Two cases of multidrug-resistant tuberculosis (MDR TB) in a household are assumed to reflect within-household transmission. However, in high-incidence areas of MDR TB, secondary cases may arise through exposure to MDR TB in the community. To estimate the frequency of multiple introductions of MDR TB into households, we used spoligotyping and 24-loci mycobacterial interspersed repetitive unit- variable number tandem repeats to classify isolates from 101 households in Lima, Peru, in which >1 MDR TB patient received treatment during 1996-2004. We found different MDR TB strains in >10% of households. Alternate approaches for classifying matching strains produced estimates of multiple introductions in
Original languageEnglish
Pages (from-to)969-975
Number of pages7
JournalEmerging Infectious Diseases
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 2011

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