Multiple loci on 8q24 associated with prostate cancer susceptibility

Ali Amin Al Olama, Zsofia Kote-Jarai, Graham G Giles, Michelle Guy, Jonathan Morrison, Gianluca Severi, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Sameer Jhavar, Ed Saunders, John L Hopper, Melissa C Southey, Kenneth R Muir, Dallas R English, David P Dearnaley, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Emma SawyerArtitaya Lophatananon, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin Cooper, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind A Eeles, Douglas F Easton, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

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Abstract

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.
Original languageEnglish
Pages (from-to)1058-60
Number of pages3
JournalNature Genetics
Volume41
Issue number10
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Chromosomes, Human, Pair 8
  • Disease Susceptibility
  • Genome, Human
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms
  • Risk Factors

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