@article{d1801b9cf7c2427d88d7496a8f1b403a,
title = "Multiple loci on 8q24 associated with prostate cancer susceptibility",
abstract = "Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.",
keywords = "Chromosomes, Human, Pair 8, Disease Susceptibility, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors",
author = "{Al Olama}, {Ali Amin} and Zsofia Kote-Jarai and Giles, {Graham G} and Michelle Guy and Jonathan Morrison and Gianluca Severi and Leongamornlert, {Daniel A} and Malgorzata Tymrakiewicz and Sameer Jhavar and Ed Saunders and Hopper, {John L} and Southey, {Melissa C} and Muir, {Kenneth R} and English, {Dallas R} and Dearnaley, {David P} and Ardern-Jones, {Audrey T} and Hall, {Amanda L} and O'Brien, {Lynne T} and Wilkinson, {Rosemary A} and Emma Sawyer and Artitaya Lophatananon and Alan Horwich and Huddart, {Robert A} and Khoo, {Vincent S} and Parker, {Christopher C} and Woodhouse, {Christopher J} and Alan Thompson and Tim Christmas and Chris Ogden and Colin Cooper and Donovan, {Jenny L} and Hamdy, {Freddie C} and Neal, {David E} and Eeles, {Rosalind A} and Easton, {Douglas F} and {UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology}",
year = "2009",
month = oct,
doi = "10.1038/ng.452",
language = "English",
volume = "41",
pages = "1058--60",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",
}