Multiple loci on 8q24 associated with prostate cancer susceptibility

Ali Amin Al Olama; Zsofia Kote-Jarai; Graham G Giles; Michelle Guy; Jonathan Morrison; Gianluca Severi; Daniel A Leongamornlert; Malgorzata Tymrakiewicz; Sameer Jhavar; Ed Saunders; John L Hopper; Melissa C Southey; Kenneth R Muir; Dallas R English; David P Dearnaley; Audrey T Ardern-Jones; Amanda L Hall; Lynne T O'Brien; Rosemary A Wilkinson; Emma Sawyer; Artitaya Lophatananon; Alan Horwich; Robert A Huddart; Vincent S Khoo; Christopher C Parker; Christopher J Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Colin Cooper; Jenny L Donovan; Freddie C Hamdy; David E Neal; Rosalind A Eeles; Douglas F Easton; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

doi:10.1038/ng.452

Multiple loci on 8q24 associated with prostate cancer susceptibility

Ali Amin Al Olama
, Zsofia Kote-Jarai
, Graham G Giles
, Michelle Guy
, Jonathan Morrison
, Gianluca Severi
, Daniel A Leongamornlert
, Malgorzata Tymrakiewicz
, Sameer Jhavar
, Ed Saunders
, John L Hopper
, Melissa C Southey
, Kenneth R Muir
, Dallas R English
, David P Dearnaley
, Audrey T Ardern-Jones
, Amanda L Hall
, Lynne T O'Brien
, Rosemary A Wilkinson
, Emma Sawyer

Artitaya Lophatananon, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin Cooper, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind A Eeles, Douglas F Easton, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

Research output: Contribution to journal › Article › peer-review

258 Citations (Scopus)

Abstract

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

Original language	English
Pages (from-to)	1058-60
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1038/ng.452
Publication status	Published - Oct 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Chromosomes, Human, Pair 8
Disease Susceptibility
Genome, Human
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide
Prostatic Neoplasms
Risk Factors

Access to Document

10.1038/ng.452

Cite this

Al Olama, A. A., Kote-Jarai, Z., Giles, G. G., Guy, M., Morrison, J., Severi, G., Leongamornlert, D. A., Tymrakiewicz, M., Jhavar, S., Saunders, E., Hopper, J. L., Southey, M. C., Muir, K. R., English, D. R., Dearnaley, D. P., Ardern-Jones, A. T., Hall, A. L., O'Brien, L. T., Wilkinson, R. A., ... UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology (2009). Multiple loci on 8q24 associated with prostate cancer susceptibility. Nature Genetics, 41(10), 1058-60. https://doi.org/10.1038/ng.452

@article{d1801b9cf7c2427d88d7496a8f1b403a,

title = "Multiple loci on 8q24 associated with prostate cancer susceptibility",

abstract = "Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.",

keywords = "Chromosomes, Human, Pair 8, Disease Susceptibility, Genome, Human, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors",

author = "\{Al Olama\}, \{Ali Amin\} and Zsofia Kote-Jarai and Giles, \{Graham G\} and Michelle Guy and Jonathan Morrison and Gianluca Severi and Leongamornlert, \{Daniel A\} and Malgorzata Tymrakiewicz and Sameer Jhavar and Ed Saunders and Hopper, \{John L\} and Southey, \{Melissa C\} and Muir, \{Kenneth R\} and English, \{Dallas R\} and Dearnaley, \{David P\} and Ardern-Jones, \{Audrey T\} and Hall, \{Amanda L\} and O'Brien, \{Lynne T\} and Wilkinson, \{Rosemary A\} and Emma Sawyer and Artitaya Lophatananon and Alan Horwich and Huddart, \{Robert A\} and Khoo, \{Vincent S\} and Parker, \{Christopher C\} and Woodhouse, \{Christopher J\} and Alan Thompson and Tim Christmas and Chris Ogden and Colin Cooper and Donovan, \{Jenny L\} and Hamdy, \{Freddie C\} and Neal, \{David E\} and Eeles, \{Rosalind A\} and Easton, \{Douglas F\} and \{UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology\}",

year = "2009",

month = oct,

doi = "10.1038/ng.452",

language = "English",

volume = "41",

pages = "1058--60",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "10",

}

Al Olama, AA, Kote-Jarai, Z, Giles, GG, Guy, M, Morrison, J, Severi, G, Leongamornlert, DA, Tymrakiewicz, M, Jhavar, S, Saunders, E, Hopper, JL, Southey, MC, Muir, KR, English, DR, Dearnaley, DP, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Wilkinson, RA, Sawyer, E, Lophatananon, A, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, C, Donovan, JL, Hamdy, FC, Neal, DE, Eeles, RA, Easton, DF & UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology 2009, 'Multiple loci on 8q24 associated with prostate cancer susceptibility', Nature Genetics, vol. 41, no. 10, pp. 1058-60. https://doi.org/10.1038/ng.452

TY - JOUR

T1 - Multiple loci on 8q24 associated with prostate cancer susceptibility

AU - Al Olama, Ali Amin

AU - Kote-Jarai, Zsofia

AU - Giles, Graham G

AU - Guy, Michelle

AU - Morrison, Jonathan

AU - Severi, Gianluca

AU - Leongamornlert, Daniel A

AU - Tymrakiewicz, Malgorzata

AU - Jhavar, Sameer

AU - Saunders, Ed

AU - Hopper, John L

AU - Southey, Melissa C

AU - Muir, Kenneth R

AU - English, Dallas R

AU - Dearnaley, David P

AU - Ardern-Jones, Audrey T

AU - Hall, Amanda L

AU - O'Brien, Lynne T

AU - Wilkinson, Rosemary A

AU - Sawyer, Emma

AU - Lophatananon, Artitaya

AU - Horwich, Alan

AU - Huddart, Robert A

AU - Khoo, Vincent S

AU - Parker, Christopher C

AU - Woodhouse, Christopher J

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Cooper, Colin

AU - Donovan, Jenny L

AU - Hamdy, Freddie C

AU - Neal, David E

AU - Eeles, Rosalind A

AU - Easton, Douglas F

AU - UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

PY - 2009/10

Y1 - 2009/10

N2 - Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

AB - Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 x 10(-8); rs620861: OR = 0.90, P = 4.8 x 10(-8)). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

KW - Chromosomes, Human, Pair 8

KW - Disease Susceptibility

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Prostatic Neoplasms

KW - Risk Factors

U2 - 10.1038/ng.452

DO - 10.1038/ng.452

M3 - Article

C2 - 19767752

SN - 1061-4036

VL - 41

SP - 1058

EP - 1060

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -