Multiple newly identified loci associated with prostate cancer susceptibility

Rosalind A. Eeles; Zsofia Kote-Jarai; Graham G. Giles; Ali Amin Al Olama; Michelle Guy; Sarah K. Jugurnauth; Shani Mulholland; Daniel A. Leongamornlert; Stephen M. Edwards; Jonathan Morrison; Helen I. Field; Melissa C. Southey; Gianluca Severi; Jenny L. Donovan; Freddie C. Hamdy; David P. Dearnaley; Kenneth R. Muir; Charmaine Smith; Melisa Bagnato; Audrey T. Ardern-Jones; Amanda L. Hall; Lynne T. O'Brien; Beatrice N. Gehr-Swain; Rosemary A. Wilkinson; Angie Cox; Sarah Lewis; Paul M. Brown; Sameer G. Jhavar; Malgorzata Tymrakiewicz; Artitaya Lophatananon; Sarah L. Bryant; Alan Horwich; Robert A. Huddart; Vincent S. Khoo; Christopher C. Parker; Christopher J. Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Cyril Fisher; Charles Jamieson; Colin S. Cooper; Dallas R. English; John L. Hopper; David E. Neal; Douglas F. Easton

doi:10.1038/ng.90

Multiple newly identified loci associated with prostate cancer susceptibility

Rosalind A. Eeles, Zsofia Kote-Jarai, Graham G. Giles, Ali Amin Al Olama, Michelle Guy, Sarah K. Jugurnauth, Shani Mulholland, Daniel A. Leongamornlert, Stephen M. Edwards, Jonathan Morrison, Helen I. Field, Melissa C. Southey, Gianluca Severi, Jenny L. Donovan, Freddie C. Hamdy, David P. Dearnaley, Kenneth R. Muir, Charmaine Smith, Melisa Bagnato, Audrey T. Ardern-JonesAmanda L. Hall, Lynne T. O'Brien, Beatrice N. Gehr-Swain, Rosemary A. Wilkinson, Angie Cox, Sarah Lewis, Paul M. Brown, Sameer G. Jhavar, Malgorzata Tymrakiewicz, Artitaya Lophatananon, Sarah L. Bryant, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Cyril Fisher, Charles Jamieson, Colin S. Cooper, Dallas R. English, John L. Hopper, David E. Neal, Douglas F. Easton

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Abstract

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 × 10−8 to P = 8.7 × 10−29). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.

Original language	English
Pages (from-to)	316-321
Number of pages	6
Journal	Nature Genetics
Volume	40
Issue number	3
DOIs	https://doi.org/10.1038/ng.90
Publication status	Published - Mar 2008

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Eeles, R. A., Kote-Jarai, Z., Giles, G. G., Olama, A. A. A., Guy, M., Jugurnauth, S. K., Mulholland, S., Leongamornlert, D. A., Edwards, S. M., Morrison, J., Field, H. I., Southey, M. C., Severi, G., Donovan, J. L., Hamdy, F. C., Dearnaley, D. P., Muir, K. R., Smith, C., Bagnato, M., ... Easton, D. F. (2008). Multiple newly identified loci associated with prostate cancer susceptibility. Nature Genetics, 40(3), 316-321. https://doi.org/10.1038/ng.90

@article{e26ca912c44340ecbb98d5aae605a90a,

title = "Multiple newly identified loci associated with prostate cancer susceptibility",

abstract = "Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 × 10−8 to P = 8.7 × 10−29). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.",

author = "Eeles, {Rosalind A.} and Zsofia Kote-Jarai and Giles, {Graham G.} and Olama, {Ali Amin Al} and Michelle Guy and Jugurnauth, {Sarah K.} and Shani Mulholland and Leongamornlert, {Daniel A.} and Edwards, {Stephen M.} and Jonathan Morrison and Field, {Helen I.} and Southey, {Melissa C.} and Gianluca Severi and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Dearnaley, {David P.} and Muir, {Kenneth R.} and Charmaine Smith and Melisa Bagnato and Ardern-Jones, {Audrey T.} and Hall, {Amanda L.} and O'Brien, {Lynne T.} and Gehr-Swain, {Beatrice N.} and Wilkinson, {Rosemary A.} and Angie Cox and Sarah Lewis and Brown, {Paul M.} and Jhavar, {Sameer G.} and Malgorzata Tymrakiewicz and Artitaya Lophatananon and Bryant, {Sarah L.} and Alan Horwich and Huddart, {Robert A.} and Khoo, {Vincent S.} and Parker, {Christopher C.} and Woodhouse, {Christopher J.} and Alan Thompson and Tim Christmas and Chris Ogden and Cyril Fisher and Charles Jamieson and Cooper, {Colin S.} and English, {Dallas R.} and Hopper, {John L.} and Neal, {David E.} and Easton, {Douglas F.}",

year = "2008",

month = mar,

doi = "10.1038/ng.90",

language = "English",

volume = "40",

pages = "316--321",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "3",

}

Eeles, RA, Kote-Jarai, Z, Giles, GG, Olama, AAA, Guy, M, Jugurnauth, SK, Mulholland, S, Leongamornlert, DA, Edwards, SM, Morrison, J, Field, HI, Southey, MC, Severi, G, Donovan, JL, Hamdy, FC, Dearnaley, DP, Muir, KR, Smith, C, Bagnato, M, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Gehr-Swain, BN, Wilkinson, RA, Cox, A, Lewis, S, Brown, PM, Jhavar, SG, Tymrakiewicz, M, Lophatananon, A, Bryant, SL, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Fisher, C, Jamieson, C, Cooper, CS, English, DR, Hopper, JL, Neal, DE & Easton, DF 2008, 'Multiple newly identified loci associated with prostate cancer susceptibility', Nature Genetics, vol. 40, no. 3, pp. 316-321. https://doi.org/10.1038/ng.90

TY - JOUR

T1 - Multiple newly identified loci associated with prostate cancer susceptibility

AU - Eeles, Rosalind A.

AU - Kote-Jarai, Zsofia

AU - Giles, Graham G.

AU - Olama, Ali Amin Al

AU - Guy, Michelle

AU - Jugurnauth, Sarah K.

AU - Mulholland, Shani

AU - Leongamornlert, Daniel A.

AU - Edwards, Stephen M.

AU - Morrison, Jonathan

AU - Field, Helen I.

AU - Southey, Melissa C.

AU - Severi, Gianluca

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Dearnaley, David P.

AU - Muir, Kenneth R.

AU - Smith, Charmaine

AU - Bagnato, Melisa

AU - Ardern-Jones, Audrey T.

AU - Hall, Amanda L.

AU - O'Brien, Lynne T.

AU - Gehr-Swain, Beatrice N.

AU - Wilkinson, Rosemary A.

AU - Cox, Angie

AU - Lewis, Sarah

AU - Brown, Paul M.

AU - Jhavar, Sameer G.

AU - Tymrakiewicz, Malgorzata

AU - Lophatananon, Artitaya

AU - Bryant, Sarah L.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Fisher, Cyril

AU - Jamieson, Charles

AU - Cooper, Colin S.

AU - English, Dallas R.

AU - Hopper, John L.

AU - Neal, David E.

AU - Easton, Douglas F.

PY - 2008/3

Y1 - 2008/3

N2 - Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 × 10−8 to P = 8.7 × 10−29). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.

AB - Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml). We analyzed these samples for 541,129 SNPs using the Illumina Infinium platform. Initial putative associations were confirmed using a further 3,268 cases and 3,366 controls. We identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X (P = 2.7 × 10−8 to P = 8.7 × 10−29). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3.

UR - http://www.scopus.com/inward/record.url?scp=39749129053&partnerID=8YFLogxK

U2 - 10.1038/ng.90

DO - 10.1038/ng.90

M3 - Article

C2 - 18264097

VL - 40

SP - 316

EP - 321

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -

Multiple newly identified loci associated with prostate cancer susceptibility

Abstract

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