Abstract
We have isolated cDNA clones corresponding to a new member of the murine tissue inhibitor of metalloproteinase (TIMP) family, designated Timp-4. The nucleotide sequence predicts a protein of 22,609 Da that contains the characteristic 12 cysteine TIMP signature. TIMP-4 is more closely related to TIMP-2 and TIMP-3 than to TIMP-1 (48%, 45% and 38% identity, respectively). Analysis of Timp-4 mRNA expression in adult mouse tissues indicated a 1.2 kb transcript in brain, heart, ovary and skeletal muscle. This pattern of expression distinguishes Timp-4 from other Timps, suggesting that the TIMP-4 protein may be an important tissue-specific regulator of extracellular matrix remodelling.
Original language | English |
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Pages (from-to) | 213-217 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 401 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 20 Jan 1997 |
Keywords
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA, Complementary
- Enzyme Inhibitors
- Male
- Metalloendopeptidases
- Mice
- Molecular Sequence Data
- Proteins
- RNA
- Sequence Homology, Amino Acid
- Tissue Inhibitor of Metalloproteinases