Mutators among CTX-M beta-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance

Matthew J Ellington, David M Livermore, Tyrone L Pitt, Lucinda M C Hall, Neil Woodford

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41 Citations (Scopus)

Abstract

Fosfomycin is a possible oral treatment for lower urinary tract infections caused by Escherichia coli with CTX-M extended-spectrum beta-lactamases but is vulnerable to mutational resistance. Hypermutability among natural E. coli populations might facilitate the emergence of resistance to fosfomycin. We therefore examined the prevalence of mutators amongst urinary isolates of E. coli producing CTX-M beta-lactamases.
Original languageEnglish
Pages (from-to)848-52
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume58
Issue number4
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Anti-Bacterial Agents
  • Drug Resistance, Bacterial
  • Escherichia coli
  • Escherichia coli Infections
  • Fosfomycin
  • Humans
  • Microbial Sensitivity Tests
  • Mutation
  • Urinary Tract Infections
  • beta-Lactamases

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