Abstract
Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.
| Original language | English |
|---|---|
| Pages (from-to) | 1091-1117 |
| Number of pages | 27 |
| Journal | Natural Product Reports |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2008 |
Keywords
- INOSITOL MONOPHOSPHATASE
- INHIBITOR
- DEPENDENT FORMALDEHYDE DEHYDROGENASE
- REDUCTASE
- DISULFIDE
- CYSTEINE LIGASE MSHC
- DIBROMOTYROSINE ALKALOID
- S-CONJUGATE AMIDASE
- CORYNEBACTERIUM-GLUTAMICUM
- ANTI-SIGMA FACTOR
- STREPTOMYCES-COELICOLOR A3(2)
- MYCOBACTERIUM-TUBERCULOSIS ERDMAN
