Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

V. K. Jothivasan, C. J. Hamilton

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105 Citations (Scopus)

Abstract

Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.
Original languageEnglish
Pages (from-to)1091-1117
Number of pages27
JournalNatural Product Reports
Volume25
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • INOSITOL MONOPHOSPHATASE
  • INHIBITOR
  • DEPENDENT FORMALDEHYDE DEHYDROGENASE
  • REDUCTASE
  • DISULFIDE
  • CYSTEINE LIGASE MSHC
  • DIBROMOTYROSINE ALKALOID
  • S-CONJUGATE AMIDASE
  • CORYNEBACTERIUM-GLUTAMICUM
  • ANTI-SIGMA FACTOR
  • STREPTOMYCES-COELICOLOR A3(2)
  • MYCOBACTERIUM-TUBERCULOSIS ERDMAN

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