Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

V. K. Jothivasan; C. J. Hamilton

doi:10.1039/b616489g

Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

V. K. Jothivasan, C. J. Hamilton

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

Abstract

Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.

Original language	English
Pages (from-to)	1091-1117
Number of pages	27
Journal	Natural Product Reports
Volume	25
Issue number	6
DOIs	https://doi.org/10.1039/b616489g
Publication status	Published - 2008

Keywords

INOSITOL MONOPHOSPHATASE
INHIBITOR
DEPENDENT FORMALDEHYDE DEHYDROGENASE
REDUCTASE
DISULFIDE
CYSTEINE LIGASE MSHC
DIBROMOTYROSINE ALKALOID
S-CONJUGATE AMIDASE
CORYNEBACTERIUM-GLUTAMICUM
ANTI-SIGMA FACTOR
STREPTOMYCES-COELICOLOR A3(2)
MYCOBACTERIUM-TUBERCULOSIS ERDMAN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/b616489g

Cite this

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title = "Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes",

abstract = "Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.",

keywords = "INOSITOL MONOPHOSPHATASE, INHIBITOR, DEPENDENT FORMALDEHYDE DEHYDROGENASE, REDUCTASE, DISULFIDE, CYSTEINE LIGASE MSHC, DIBROMOTYROSINE ALKALOID, S-CONJUGATE AMIDASE, CORYNEBACTERIUM-GLUTAMICUM, ANTI-SIGMA FACTOR, STREPTOMYCES-COELICOLOR A3(2), MYCOBACTERIUM-TUBERCULOSIS ERDMAN",

author = "Jothivasan, {V. K.} and Hamilton, {C. J.}",

year = "2008",

doi = "10.1039/b616489g",

language = "English",

volume = "25",

pages = "1091--1117",

journal = "Natural Product Reports",

issn = "0265-0568",

publisher = "Royal Society of Chemistry",

number = "6",

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TY - JOUR

T1 - Mycothiol: synthesis, biosynthesis and biological functions of the major low molecular weight thiol in actinomycetes

AU - Jothivasan, V. K.

AU - Hamilton, C. J.

PY - 2008

Y1 - 2008

N2 - Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.

AB - Actinomycetes produce mycothiol as their major low molecular weight thiol, which parallels the functions of glutathione found in prokaryotes and most Gram-negative bacteria. This review covers progress that has so far been made in terms of its distribution, biosynthesis and metabolic functions, as well as chemical syntheses of mycothiol and alternative substrates and inhibitors of mycothiol biosynthesis and mycothiol-dependent enzymes. 152 references are cited.

KW - INOSITOL MONOPHOSPHATASE

KW - INHIBITOR

KW - DEPENDENT FORMALDEHYDE DEHYDROGENASE

KW - REDUCTASE

KW - DISULFIDE

KW - CYSTEINE LIGASE MSHC

KW - DIBROMOTYROSINE ALKALOID

KW - S-CONJUGATE AMIDASE

KW - CORYNEBACTERIUM-GLUTAMICUM

KW - ANTI-SIGMA FACTOR

KW - STREPTOMYCES-COELICOLOR A3(2)

KW - MYCOBACTERIUM-TUBERCULOSIS ERDMAN

U2 - 10.1039/b616489g

DO - 10.1039/b616489g

M3 - Article

VL - 25

SP - 1091

EP - 1117

JO - Natural Product Reports

JF - Natural Product Reports

SN - 0265-0568

IS - 6

ER -