Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells

Jeffrey K. Huang, Stephen P.J. Fancy, Chao Zhao, David H. Rowitch, Charles ffrench-Constant, Robin J.M. Franklin

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)

Abstract

Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination.

Original languageEnglish
Pages (from-to)650-658
Number of pages9
JournalNeurotherapeutics
Volume8
Issue number4
DOIs
Publication statusPublished - 9 Sep 2011

Keywords

  • Multiple sclerosis
  • Regenerative medicine
  • Remyelination
  • Stem cell

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