Abstract
Multiple myeloma (MM) remains an incurable malignancy despite the recent advancements in its treatment. The protective effects of the niche in which it develops has been well documented; however, little has been done to investigate the MM cell’s ability to ‘re-program’ cells within its environment to benefit disease progression. Here, we show that MM-derived macrophage migratory inhibitory factor (MIF) stimulates bone marrow stromal cells to produce the disease critical cytokines IL-6 and IL-8, prior to any cell-cell contact. Furthermore, we provide evidence that this IL-6/8 production is mediated by the transcription factor cMYC. Pharmacological inhibition of cMYC in vivo using JQ1 led to significantly decreased levels of serum IL-6—a highly positive prognostic marker in MM patients.
Original language | English |
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Article number | 66 |
Journal | Journal of Hematology & Oncology |
Volume | 11 |
DOIs | |
Publication status | Published - 16 May 2018 |
Keywords
- Myeloma
- MIF
- cMYC
- BMSC
- StromalI
- L-6I
- L-8
- Bone marrow
Profiles
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Kristian Bowles
- Norwich Medical School - Dean of Norwich Medical School
- Cancer Studies - Member
Person: Research Group Member, Academic, Teaching & Research
-
Stuart Rushworth
- Norwich Medical School - Professor
- Metabolic Health - Director
- Cancer Studies - Member
Person: Research Group Member, Academic, Teaching & Research