@article{d1c9913d083d4dae9d642123cb10204c,
title = "Myocardial scar and remodelling predict long-term mortality in severe aortic stenosis beyond 10 years",
abstract = "Aortic stenosis (AS) is characterized by the narrowing of the aortic valve and compensatory myocardial remodelling.1 However, ultimately the left ventricle decompensates, leading to heart failure and death, and intervention is advised for severe AS accompanied by either symptoms or left ventricular (LV) dysfunction.2 Yet, over half of patients receiving aortic valve replacement (AVR) have irreversible myocardial scarring.3 Our multi-centre UK consortium linked pre-operative myocardial scarring, detected by late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) with increased all-cause and cardiovascular (CV) mortality, regardless of intervention type, after a median of 3.5 years.4 With the integration of machine learning for CMR analysis, we achieve 40% greater precision than human assessment, potentially uncovering patterns obscured by human variability.5 We now examine whether the association of myocardial scar with mortality persists over longer-term follow-up.",
author = "Thornton, {George D.} and Vassiliou, {Vassilios S.} and Musa, {Tarique A.} and Nikoo Aziminia and Neil Craig and Abhishek Dattani and Davies, {Rhodri H.} and Gabriella Captur and Moon, {James C.} and Dweck, {Marc R.} and Myerson, {Saul G.} and Prasad, {Sanjay K.} and McCann, {Gerry P.} and Greenwood, {John P.} and Anvesha Singh and Treibel, {Thomas A.} and {BSCMR AS700 Consortium}",
note = "Data Availability Statement: Data is available on request. Funding Information: This study was in part supported by the British Heart Foundation (University of Leeds, Prof Greenwood [PG/11/126/29321]; University of Leicester, Prof McCann [PG/07/068/2334]; University of Oxford, Prof Myerson [FS/10/015/28104]; University of Edinburgh, Dr Dweck [FS/10/026]; University College London, Prof Moon [FS/08/028/24767]), Dr Treibel [FS/19/35/34374], Dr Thornton [FS/CRTF/21/2412] and the National Institute for Health Research (University College London, Dr Treibel [DRF-2013-06-102]), including via its Biomedical Research Centre and Clinical Research Facility programmes, as well as Rosetrees Trust. The views expressed are those of the authors and not necessarily those of the UK National Health Service, National Institute for Health Research, or Department of Health.",
year = "2024",
month = jun,
day = "7",
doi = "10.1093/eurheartj/ehae067",
language = "English",
volume = "45",
pages = "2019–2022",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "22",
}
