N- vs. O-alkylation in 2(1H)-quinolinone derivatives

Zhao-Xia Guo, Andrew N. Cammidge, Alexander McKillop, David C. Horwell

Research output: Contribution to journalArticlepeer-review

Abstract

N- vs O-alkylation reactions of 8-benzyloxy-2(1H)-quinolinone have been investigated using both classical and phase transfer conditions. The influence of reaction solvents/conditions was found to have a dramatic effect on selectivity, with opposite trends to that observed for 2-pyridone alkylation.
Original languageEnglish
Pages (from-to)6999-7002
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number38
DOIs
Publication statusPublished - 17 Sep 1999

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